Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian Children and Adults with Uncomplicated Falciparum Malaria

M.B. Denis, Timothy Davis, S. Hewitt, S. Incardona, K. Nimol, T. Fandeur, Y. Poravuth, C. Lim, D. Socheat

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    Abstract

    The safety and efficacy of a novel combination of dihydroartemisinin (DHA) and piperaquine, Artekin (Holleykin Pharmaceuticals), were assessed in 106 patients (76 children and 30 adults) with uncomplicated falciparum malaria from 2 remote areas in Cambodia. Age-based doses were given at 0, 8, 24, and 32 h. Mean total DHA and piperaquine doses were 9. 1 and 73.9 mg/ kg, respectively, for children and 6.6 and 52.9 mg/ kg for adults. All patients became aparasitemic within 72 h. Excluding the results for 1 child who died on day 4, there was a 96.9% 28- day cure rate (98.6% in children and 92.3% in adults). Patients who had recrudescent infection received low doses of Artekin. Side effects were reported by 22 patients (21%) but did not necessitate premature cessation of therapy. Although Artekin is a promising and inexpensive option for antimalarial therapy, further efficacy and pharmacokinetic studies are needed, especially for its use in children.
    Original languageEnglish
    Pages (from-to)1469-1476
    JournalClinical Infectious Diseases
    Volume35
    Issue number15 December
    DOIs
    Publication statusPublished - 2002

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