TY - JOUR
T1 - Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian Children and Adults with Uncomplicated Falciparum Malaria
AU - Denis, M.B.
AU - Davis, Timothy
AU - Hewitt, S.
AU - Incardona, S.
AU - Nimol, K.
AU - Fandeur, T.
AU - Poravuth, Y.
AU - Lim, C.
AU - Socheat, D.
PY - 2002
Y1 - 2002
N2 - The safety and efficacy of a novel combination of dihydroartemisinin (DHA) and piperaquine, Artekin (Holleykin Pharmaceuticals), were assessed in 106 patients (76 children and 30 adults) with uncomplicated falciparum malaria from 2 remote areas in Cambodia. Age-based doses were given at 0, 8, 24, and 32 h. Mean total DHA and piperaquine doses were 9. 1 and 73.9 mg/ kg, respectively, for children and 6.6 and 52.9 mg/ kg for adults. All patients became aparasitemic within 72 h. Excluding the results for 1 child who died on day 4, there was a 96.9% 28- day cure rate (98.6% in children and 92.3% in adults). Patients who had recrudescent infection received low doses of Artekin. Side effects were reported by 22 patients (21%) but did not necessitate premature cessation of therapy. Although Artekin is a promising and inexpensive option for antimalarial therapy, further efficacy and pharmacokinetic studies are needed, especially for its use in children.
AB - The safety and efficacy of a novel combination of dihydroartemisinin (DHA) and piperaquine, Artekin (Holleykin Pharmaceuticals), were assessed in 106 patients (76 children and 30 adults) with uncomplicated falciparum malaria from 2 remote areas in Cambodia. Age-based doses were given at 0, 8, 24, and 32 h. Mean total DHA and piperaquine doses were 9. 1 and 73.9 mg/ kg, respectively, for children and 6.6 and 52.9 mg/ kg for adults. All patients became aparasitemic within 72 h. Excluding the results for 1 child who died on day 4, there was a 96.9% 28- day cure rate (98.6% in children and 92.3% in adults). Patients who had recrudescent infection received low doses of Artekin. Side effects were reported by 22 patients (21%) but did not necessitate premature cessation of therapy. Although Artekin is a promising and inexpensive option for antimalarial therapy, further efficacy and pharmacokinetic studies are needed, especially for its use in children.
U2 - 10.1086/344647
DO - 10.1086/344647
M3 - Article
SN - 1058-4838
VL - 35
SP - 1469
EP - 1476
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 15 December
ER -