Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women

A. Devine, C. Rosen, S. Mohan, D. Baylink, Richard Prince

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Abstract

Insulin-like growth factor I (IGF-I) is a critical factor in the regulation of various physiologic effects, including bone formation and protein metabolism. Nutrient intake is a main regulator of circulating IGF-I. The relation of zinc status and IGF-I in adulthood has not been studied adequately even though suboptimal intakes of zinc are reported widely in the elderly. This study examined the relation between calculated nutrient intakes from 119 postmenopausal women and concentrations of IGF-I and IGF binding proteins (IGFBPs). Dietary intake was evaluated by 4-d weighed diet records at baseline and 2 y. Mean intakes of 25 nutrients were calculated. Concentrations of IGF-I and IGFBPs were measured by radioimmunoassays at baseline and 2 y. Mean age (63 +/- 4 y), weight (66 +/- 9 kg), and nutrient intake were correlated with the mean IGF-I concentration at baseline (172 +/- 57 mu g/L) and 2 y (142 +/- 43 mu g/L). IGF-I concentrations were significantly correlated with mean protein and zinc intake at baseline (r = 0.313, P = 0.001; r = 0.298, P = 0.001, respectively) and 2 y (r = 0.256, P = 0.008; r = 0.331, P = 0.001, respectively). After age, weight, and other nutrient intakes were adjusted for in multiple regression at baseline and 2 y, zinc remained the major determinant of IGF-I concentrations. These results suggest that low zinc intake is associated with low IGF-I concentrations in healthy postmenopausal women and that the effects of zinc may be independent of protein intake.
Original languageEnglish
Pages (from-to)200-6
JournalAmerican Journal of Clinical Nutrition
Volume68
Issue number1
Publication statusPublished - 1998

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Insulin-Like Growth Factor Binding Proteins
Insulin-Like Growth Factor I
Zinc
Food
Diet Records
Weights and Measures
Proteins
Osteogenesis
Radioimmunoassay

Cite this

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title = "Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women",
abstract = "Insulin-like growth factor I (IGF-I) is a critical factor in the regulation of various physiologic effects, including bone formation and protein metabolism. Nutrient intake is a main regulator of circulating IGF-I. The relation of zinc status and IGF-I in adulthood has not been studied adequately even though suboptimal intakes of zinc are reported widely in the elderly. This study examined the relation between calculated nutrient intakes from 119 postmenopausal women and concentrations of IGF-I and IGF binding proteins (IGFBPs). Dietary intake was evaluated by 4-d weighed diet records at baseline and 2 y. Mean intakes of 25 nutrients were calculated. Concentrations of IGF-I and IGFBPs were measured by radioimmunoassays at baseline and 2 y. Mean age (63 +/- 4 y), weight (66 +/- 9 kg), and nutrient intake were correlated with the mean IGF-I concentration at baseline (172 +/- 57 mu g/L) and 2 y (142 +/- 43 mu g/L). IGF-I concentrations were significantly correlated with mean protein and zinc intake at baseline (r = 0.313, P = 0.001; r = 0.298, P = 0.001, respectively) and 2 y (r = 0.256, P = 0.008; r = 0.331, P = 0.001, respectively). After age, weight, and other nutrient intakes were adjusted for in multiple regression at baseline and 2 y, zinc remained the major determinant of IGF-I concentrations. These results suggest that low zinc intake is associated with low IGF-I concentrations in healthy postmenopausal women and that the effects of zinc may be independent of protein intake.",
author = "A. Devine and C. Rosen and S. Mohan and D. Baylink and Richard Prince",
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language = "English",
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T1 - Effects of zinc and other nutritional factors on insulin-like growth factor I and insulin-like growth factor binding proteins in postmenopausal women

AU - Devine, A.

AU - Rosen, C.

AU - Mohan, S.

AU - Baylink, D.

AU - Prince, Richard

PY - 1998

Y1 - 1998

N2 - Insulin-like growth factor I (IGF-I) is a critical factor in the regulation of various physiologic effects, including bone formation and protein metabolism. Nutrient intake is a main regulator of circulating IGF-I. The relation of zinc status and IGF-I in adulthood has not been studied adequately even though suboptimal intakes of zinc are reported widely in the elderly. This study examined the relation between calculated nutrient intakes from 119 postmenopausal women and concentrations of IGF-I and IGF binding proteins (IGFBPs). Dietary intake was evaluated by 4-d weighed diet records at baseline and 2 y. Mean intakes of 25 nutrients were calculated. Concentrations of IGF-I and IGFBPs were measured by radioimmunoassays at baseline and 2 y. Mean age (63 +/- 4 y), weight (66 +/- 9 kg), and nutrient intake were correlated with the mean IGF-I concentration at baseline (172 +/- 57 mu g/L) and 2 y (142 +/- 43 mu g/L). IGF-I concentrations were significantly correlated with mean protein and zinc intake at baseline (r = 0.313, P = 0.001; r = 0.298, P = 0.001, respectively) and 2 y (r = 0.256, P = 0.008; r = 0.331, P = 0.001, respectively). After age, weight, and other nutrient intakes were adjusted for in multiple regression at baseline and 2 y, zinc remained the major determinant of IGF-I concentrations. These results suggest that low zinc intake is associated with low IGF-I concentrations in healthy postmenopausal women and that the effects of zinc may be independent of protein intake.

AB - Insulin-like growth factor I (IGF-I) is a critical factor in the regulation of various physiologic effects, including bone formation and protein metabolism. Nutrient intake is a main regulator of circulating IGF-I. The relation of zinc status and IGF-I in adulthood has not been studied adequately even though suboptimal intakes of zinc are reported widely in the elderly. This study examined the relation between calculated nutrient intakes from 119 postmenopausal women and concentrations of IGF-I and IGF binding proteins (IGFBPs). Dietary intake was evaluated by 4-d weighed diet records at baseline and 2 y. Mean intakes of 25 nutrients were calculated. Concentrations of IGF-I and IGFBPs were measured by radioimmunoassays at baseline and 2 y. Mean age (63 +/- 4 y), weight (66 +/- 9 kg), and nutrient intake were correlated with the mean IGF-I concentration at baseline (172 +/- 57 mu g/L) and 2 y (142 +/- 43 mu g/L). IGF-I concentrations were significantly correlated with mean protein and zinc intake at baseline (r = 0.313, P = 0.001; r = 0.298, P = 0.001, respectively) and 2 y (r = 0.256, P = 0.008; r = 0.331, P = 0.001, respectively). After age, weight, and other nutrient intakes were adjusted for in multiple regression at baseline and 2 y, zinc remained the major determinant of IGF-I concentrations. These results suggest that low zinc intake is associated with low IGF-I concentrations in healthy postmenopausal women and that the effects of zinc may be independent of protein intake.

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