Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 283-288 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 75 |
| Publication status | Published - 2002 |
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Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women. / Devine, A.; Wilson, S.G.; Dick, Ian; Prince, Richard.
In: American Journal of Clinical Nutrition, Vol. 75, 2002, p. 283-288.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women
AU - Devine, A.
AU - Wilson, S.G.
AU - Dick, Ian
AU - Prince, Richard
PY - 2002
Y1 - 2002
N2 - Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11%) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.
AB - Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11%) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.
M3 - Article
VL - 75
SP - 283
EP - 288
JO - The American Journal of Clinical Nutrition
JF - The American Journal of Clinical Nutrition
SN - 0002-9165
ER -