Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women

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Abstract

Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11%) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.
Original languageEnglish
Pages (from-to)283-288
JournalAmerican Journal of Clinical Nutrition
Volume75
Publication statusPublished - 2002

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Bone Remodeling
Intestinal Absorption
Vitamin D
Calcium
Calcitriol
Dietary Calcium
Sunlight
Radioactive Tracers

Cite this

@article{3ecd49578cde448caa943d9078719ea7,
title = "Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women",
abstract = "Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11{\%}) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.",
author = "A. Devine and S.G. Wilson and Ian Dick and Richard Prince",
year = "2002",
language = "English",
volume = "75",
pages = "283--288",
journal = "The American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",

}

TY - JOUR

T1 - Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women

AU - Devine, A.

AU - Wilson, S.G.

AU - Dick, Ian

AU - Prince, Richard

PY - 2002

Y1 - 2002

N2 - Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11%) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.

AB - Background: The relative importance of vitamin D metabolites in the regulation of gut calcium absorption has not been well studied in elderly women living in an environment with abundant sunlight.Objective: The objective was to examine the determinants of active gut calcium absorption ((x) over bar +/- SD: 42 +/- 11%) after an overnight fast with the use of a low (10 mg) calcium load.Design: One hundred twenty elderly women aged 74.7 +/- 2.6 y underwent an active calcium absorption test with a radioactive calcium tracer, dietary analysis, and measurement of markers of bone turnover and calcium metabolism.Results: The mean serum 25-hydroxyvitamin D [25(OH)D] concentration at the time of the calcium absorption test was 68 +/- 29 nmol/L. Gut calcium absorption was correlated with 25(OH)D but not 1,25-dihydroxyvitamin D (calcitriol), the free calcitriol index, or dietary calcium intake. After adjustment for age, calcitriol concentration, and dietary calcium intake, the significant determinant of fractional calcium absorption was the 25(OH)D concentration (r = 0.34, P = 0.001). When body weight was included in the regression, both 25 (OH)D (beta = 1.20 X 10(-3)) and calcitriol (beta = 1.00 X 10(-3)) were significantly correlated with calcium absorption. Despite the strong relation between 25(OH)D and gut calcium absorption, there was no relation with other aspects of bone turnover or calcium metabolism.Conclusion: These data suggest that at low calcium loads, 25(OH)D is a more important determinant of gut calcium absorption than is calcitriol in elderly women exposed to abundant sunlight, but that this relation has little effect on overall calcium metabolism.

M3 - Article

VL - 75

SP - 283

EP - 288

JO - The American Journal of Clinical Nutrition

JF - The American Journal of Clinical Nutrition

SN - 0002-9165

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