Effects of therapeutic lifestyle change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects

Esther Ooi, A.H. Lichtenstein, J.S. Millar, M.R. Diffenderfer, S. Lamon-Fava, H. Rasmussen, F.K. Welty, Hugh Barrett, E.J. Schaefer

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Abstract

The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23%), production rate (PR, −9%), and direct catabolism (−53%), and increased TRL-to-LDL apoB-100 conversion (+39%) as compared with the baseline diet (all P < 0.05). This diet also decreased TRL apoB-48 concentration (−24%), fractional catabolic rate (FCR, −20%), and PR (−50%) as compared with the baseline diet (all P < 0.05). The high-fish and low-fish diets decreased LDL apoB-100 concentration (−9%, −23%), increased LDL apoB-100 FCR (+44%, +48%), and decreased HDL apoA-I concentration (−15%, −14%) and PR (−11%, −12%) as compared with the baseline diet (all P < 0.05). On the high-fish diet, changes in TRL apoB-100 PR were negatively correlated with changes in plasma eicosapentaenoic and docosahexaenoic acids. In conclusion, the high-fish diet decreased TRL apoB-100 and TRL apoB-48 concentrations chiefly by decreasing their PR. Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR.
Original languageEnglish
Pages (from-to)1958-1967
JournalJournal of Lipid Research
Volume53
Early online date6 Jul 2012
DOIs
Publication statusPublished - Sep 2012

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Therapeutic Uses
Nutrition
Apolipoprotein B-100
Metabolism
Fish
Lipoproteins
Life Style
Fishes
Diet
Triglycerides
Apolipoprotein A-I
Apolipoprotein B-48
Apolipoproteins
Eicosapentaenoic Acid
Docosahexaenoic Acids
LDL Lipoproteins
Isotopes
oxidized low density lipoprotein
Plasmas

Cite this

Ooi, Esther ; Lichtenstein, A.H. ; Millar, J.S. ; Diffenderfer, M.R. ; Lamon-Fava, S. ; Rasmussen, H. ; Welty, F.K. ; Barrett, Hugh ; Schaefer, E.J. / Effects of therapeutic lifestyle change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects. In: Journal of Lipid Research. 2012 ; Vol. 53. pp. 1958-1967.
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abstract = "The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23{\%}), production rate (PR, −9{\%}), and direct catabolism (−53{\%}), and increased TRL-to-LDL apoB-100 conversion (+39{\%}) as compared with the baseline diet (all P < 0.05). This diet also decreased TRL apoB-48 concentration (−24{\%}), fractional catabolic rate (FCR, −20{\%}), and PR (−50{\%}) as compared with the baseline diet (all P < 0.05). The high-fish and low-fish diets decreased LDL apoB-100 concentration (−9{\%}, −23{\%}), increased LDL apoB-100 FCR (+44{\%}, +48{\%}), and decreased HDL apoA-I concentration (−15{\%}, −14{\%}) and PR (−11{\%}, −12{\%}) as compared with the baseline diet (all P < 0.05). On the high-fish diet, changes in TRL apoB-100 PR were negatively correlated with changes in plasma eicosapentaenoic and docosahexaenoic acids. In conclusion, the high-fish diet decreased TRL apoB-100 and TRL apoB-48 concentrations chiefly by decreasing their PR. Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR.",
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Effects of therapeutic lifestyle change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects. / Ooi, Esther; Lichtenstein, A.H.; Millar, J.S.; Diffenderfer, M.R.; Lamon-Fava, S.; Rasmussen, H.; Welty, F.K.; Barrett, Hugh; Schaefer, E.J.

In: Journal of Lipid Research, Vol. 53, 09.2012, p. 1958-1967.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of therapeutic lifestyle change diets high and low in dietary fish-derived FAs on lipoprotein metabolism in middle-aged and elderly subjects

AU - Ooi, Esther

AU - Lichtenstein, A.H.

AU - Millar, J.S.

AU - Diffenderfer, M.R.

AU - Lamon-Fava, S.

AU - Rasmussen, H.

AU - Welty, F.K.

AU - Barrett, Hugh

AU - Schaefer, E.J.

PY - 2012/9

Y1 - 2012/9

N2 - The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23%), production rate (PR, −9%), and direct catabolism (−53%), and increased TRL-to-LDL apoB-100 conversion (+39%) as compared with the baseline diet (all P < 0.05). This diet also decreased TRL apoB-48 concentration (−24%), fractional catabolic rate (FCR, −20%), and PR (−50%) as compared with the baseline diet (all P < 0.05). The high-fish and low-fish diets decreased LDL apoB-100 concentration (−9%, −23%), increased LDL apoB-100 FCR (+44%, +48%), and decreased HDL apoA-I concentration (−15%, −14%) and PR (−11%, −12%) as compared with the baseline diet (all P < 0.05). On the high-fish diet, changes in TRL apoB-100 PR were negatively correlated with changes in plasma eicosapentaenoic and docosahexaenoic acids. In conclusion, the high-fish diet decreased TRL apoB-100 and TRL apoB-48 concentrations chiefly by decreasing their PR. Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR.

AB - The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apolipoprotein kinetics were determined in the fed state using stable isotope methods and compartmental modeling at the end of each phase. Only the high-fish diet decreased median triglyceride-rich lipoprotein (TRL) apoB-100 concentration (−23%), production rate (PR, −9%), and direct catabolism (−53%), and increased TRL-to-LDL apoB-100 conversion (+39%) as compared with the baseline diet (all P < 0.05). This diet also decreased TRL apoB-48 concentration (−24%), fractional catabolic rate (FCR, −20%), and PR (−50%) as compared with the baseline diet (all P < 0.05). The high-fish and low-fish diets decreased LDL apoB-100 concentration (−9%, −23%), increased LDL apoB-100 FCR (+44%, +48%), and decreased HDL apoA-I concentration (−15%, −14%) and PR (−11%, −12%) as compared with the baseline diet (all P < 0.05). On the high-fish diet, changes in TRL apoB-100 PR were negatively correlated with changes in plasma eicosapentaenoic and docosahexaenoic acids. In conclusion, the high-fish diet decreased TRL apoB-100 and TRL apoB-48 concentrations chiefly by decreasing their PR. Both diets decreased LDL apoB-100 concentration by increasing LDL apoB-100 FCR and decreased HDL apoA-I concentration by decreasing HDL apoA-I PR.

U2 - 10.1194/jlr.P024315

DO - 10.1194/jlr.P024315

M3 - Article

VL - 53

SP - 1958

EP - 1967

JO - Journal of Lipid Research

JF - Journal of Lipid Research

SN - 0022-2275

ER -