Effects of statins on renin–angiotensin system

Nasim Kiaie, Armita Mahdavi Gorabi, Željko Reiner, Tannaz Jamialahmadi, Massimiliano Ruscica, Amirhossein Sahebkar

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.

Original languageEnglish
Article number80
JournalJournal of Cardiovascular Development and Disease
Issue number7
Publication statusPublished - Jul 2021


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