TY - JOUR
T1 - Effects of statins on renin–angiotensin system
AU - Kiaie, Nasim
AU - Gorabi, Armita Mahdavi
AU - Reiner, Željko
AU - Jamialahmadi, Tannaz
AU - Ruscica, Massimiliano
AU - Sahebkar, Amirhossein
PY - 2021/7
Y1 - 2021/7
N2 - Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.
AB - Statins, a class of drugs for lowering serum LDL-cholesterol, have attracted attention because of their wide range of pleiotropic effects. An important but often neglected effect of statins is their role in the renin–angiotensin system (RAS) pathway. This pathway plays an integral role in the progression of several diseases including hypertension, heart failure, and renal disease. In this paper, the role of statins in the blockade of different components of this pathway and the underlying mechanisms are reviewed and new therapeutic possibilities of statins are suggested.
KW - Hypertension
KW - Renin–angiotensin system (RAS)
KW - Statins
UR - http://www.scopus.com/inward/record.url?scp=85110891453&partnerID=8YFLogxK
U2 - 10.3390/jcdd8070080
DO - 10.3390/jcdd8070080
M3 - Article
C2 - 34357323
AN - SCOPUS:85110891453
VL - 8
JO - Journal of Cardiovascular Development and Disease
JF - Journal of Cardiovascular Development and Disease
IS - 7
M1 - 80
ER -