Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry

Felix Mahfoud, Michael Böhm, Roland Schmieder, Krzysztof Narkiewicz, Sebastian Ewen, Luis Ruilope, Markus Schlaich, Bryan Williams, Martin Fahy, Giuseppe Mancia

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Abstract

AIMS: Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. METHODS AND RESULTS: The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (-16.5 ± 28.6 mmHg, P 

Original languageEnglish
Pages (from-to)3474-3482
Number of pages9
JournalEuropean Heart Journal
Volume40
Issue number42
DOIs
Publication statusPublished - 1 Nov 2019

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Mahfoud, F., Böhm, M., Schmieder, R., Narkiewicz, K., Ewen, S., Ruilope, L., ... Mancia, G. (2019). Effects of renal denervation on kidney function and long-term outcomes: 3-year follow-up from the Global SYMPLICITY Registry. European Heart Journal, 40(42), 3474-3482. https://doi.org/10.1093/eurheartj/ehz118