TY - JOUR
T1 - Effects of renal denervation on kidney function and long-term outcomes
T2 - 3-year follow-up from the Global SYMPLICITY Registry
AU - Mahfoud, Felix
AU - Böhm, Michael
AU - Schmieder, Roland
AU - Narkiewicz, Krzysztof
AU - Ewen, Sebastian
AU - Ruilope, Luis
AU - Schlaich, Markus
AU - Williams, Bryan
AU - Fahy, Martin
AU - Mancia, Giuseppe
PY - 2019/11/1
Y1 - 2019/11/1
N2 - AIMS: Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. METHODS AND RESULTS: The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (-16.5 ± 28.6 mmHg, P
AB - AIMS: Several studies and registries have demonstrated sustained reductions in blood pressure (BP) after renal denervation (RDN). The long-term safety and efficacy after RDN in real-world patients with uncontrolled hypertension, however, remains unknown. The objective of this study was to assess the long-term safety and efficacy of RDN, including its effects on renal function. METHODS AND RESULTS: The Global SYMPLICITY Registry is a prospective, open-label registry conducted at 196 active sites worldwide in hypertensive patients receiving RDN treatment. Among 2237 patients enrolled and treated with the SYMPLICITY Flex catheter, 1742 were eligible for follow-up at 3 years. Baseline office and 24-h ambulatory systolic BP (SBP) were 166 ± 25 and 154 ± 18 mmHg, respectively. SBP reduction after RDN was sustained over 3 years, including decreases in both office (-16.5 ± 28.6 mmHg, P
KW - Ambulatory blood pressure monitoring
KW - Denervation
KW - Hypertension
KW - Renal function
KW - SYMPLICITY
UR - http://www.scopus.com/inward/record.url?scp=85065919895&partnerID=8YFLogxK
U2 - 10.1093/eurheartj/ehz118
DO - 10.1093/eurheartj/ehz118
M3 - Article
C2 - 30907413
AN - SCOPUS:85065919895
SN - 0195-668X
VL - 40
SP - 3474
EP - 3482
JO - European Heart Journal
JF - European Heart Journal
IS - 42
ER -