TY - JOUR
T1 - Effects of regular ingestion of black tea on haemostasis and cell adhesion molecules in humans
AU - Hodgson, Jonathan
AU - Puddey, Ian
AU - Mori, Trevor
AU - Burke, Valerie
AU - Baker, R.
AU - Beilin, Lawrence
PY - 2001
Y1 - 2001
N2 - Objective: To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules.Design: Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effects of 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake.Results: The 24 It urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P
AB - Objective: To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules.Design: Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effects of 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasma concentrations of coagulation and fibrinolytic factors (fibrinogen, factor VII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of 4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake.Results: The 24 It urinary excretion of 4OMGA was increased during regular ingestion of black tea in comparison to hot water (P
U2 - 10.1038/sj.ejcn.1601231
DO - 10.1038/sj.ejcn.1601231
M3 - Article
C2 - 11593350
SN - 0954-3007
VL - 55
SP - 881
EP - 886
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
ER -