Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial

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Abstract

Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3.7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P

Original languageEnglish
Pages (from-to)971-980
Number of pages10
JournalBritish Journal of Nutrition
Volume118
Issue number11
DOIs
Publication statusPublished - 14 Dec 2017

Cite this

@article{008e024705f8431383472272d43f0f59,
title = "Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age: a double-blind, randomised controlled clinical trial",
abstract = "Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3.7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P",
keywords = "n-3 Fatty acid supplementation, Pregnancy, Resolvins, Protectins, Inflammation, FISH-OIL SUPPLEMENTATION, DAMPENS AIRWAY INFLAMMATION, LIPID MEDIATORS, HIGH-RISK, PROTECTIN D1, CORD-BLOOD, DOCOSAHEXAENOIC ACID, EXPERIMENTAL COLITIS, PROMOTE RESOLUTION, MURINE MODEL",
author = "See, {Valene H. L.} and Emilie Mas and Prescott, {Susan L.} and Beilin, {Lawrence J.} and Sally Burrows and Barden, {Anne E.} and Rae-Chi Huang and Mori, {Trevor A.}",
year = "2017",
month = "12",
day = "14",
doi = "10.1017/S0007114517002914",
language = "English",
volume = "118",
pages = "971--980",
journal = "The British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "11",

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TY - JOUR

T1 - Effects of prenatal n-3 fatty acid supplementation on offspring resolvins at birth and 12 years of age

T2 - a double-blind, randomised controlled clinical trial

AU - See, Valene H. L.

AU - Mas, Emilie

AU - Prescott, Susan L.

AU - Beilin, Lawrence J.

AU - Burrows, Sally

AU - Barden, Anne E.

AU - Huang, Rae-Chi

AU - Mori, Trevor A.

PY - 2017/12/14

Y1 - 2017/12/14

N2 - Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3.7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P

AB - Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. n-3 Fatty acid supplementation during pregnancy may provide an intervention strategy to modify these novel SPM. This study aimed to assess the effect of n-3 fatty acid supplementation in pregnancy on offspring SPM at birth and 12 years of age (12 years). In all, ninety-eight atopic pregnant women were randomised to 3.7 g daily n-3 fatty acids or a control (olive oil), from 20 weeks gestation until delivery. Blood was collected from the offspring at birth and at 12 years. Plasma SPM consisting of 18-hydroxyeicosapentaenoic acid (18-HEPE), E-series resolvins, 17-hydroxydocosahexaenoic acid (17-HDHA), D-series resolvins, 14-hydroxydocosahexaenoic acid (14-HDHA), 10 S,17S-dihydroxydocosahexaenoic acid, maresins and protectin 1, were measured by liquid chromatography-tandem MS. We identified the resolvins RvE1, RvE2, RvE3, RvD1, 17R-RvD1 and RvD2 for the first time in human cord blood. n-3 Fatty acids increased cord blood 18-HEPE (P

KW - n-3 Fatty acid supplementation

KW - Pregnancy

KW - Resolvins

KW - Protectins

KW - Inflammation

KW - FISH-OIL SUPPLEMENTATION

KW - DAMPENS AIRWAY INFLAMMATION

KW - LIPID MEDIATORS

KW - HIGH-RISK

KW - PROTECTIN D1

KW - CORD-BLOOD

KW - DOCOSAHEXAENOIC ACID

KW - EXPERIMENTAL COLITIS

KW - PROMOTE RESOLUTION

KW - MURINE MODEL

U2 - 10.1017/S0007114517002914

DO - 10.1017/S0007114517002914

M3 - Article

VL - 118

SP - 971

EP - 980

JO - The British Journal of Nutrition

JF - The British Journal of Nutrition

SN - 0007-1145

IS - 11

ER -