Effects of Pediatric Burns on Gastrointestinal Diseases: A Population-Based Study

James H. Boyd, Fiona M. Wood, Sean M. Randall, Mark W. Fear, Suzanne Rea, Janine M. Duke

    Research output: Contribution to journalArticle

    Abstract

    The systemic responses triggered by burns have been shown to include effects on the gastrointestinal tract. However, it is not clear if these changes lead to long-term gastrointestinal morbidity in patients with burns. The aim of this study was to assess if pediatric burns are associated with increased hospital use for gastrointestinal diseases after discharge for the initial injury. A population-based longitudinal study was performed using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10,436) between 1980 and 2012, along with a frequency-matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40,819). Crude admission rates and cumulative length of stay for digestive diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios (IRRs) and hazard ratios, respectively. After discharge, the pediatric burn cohort experienced twice the rate of gastrointestinal disease admissions (IRR, 95% confidence interval [CI]: 2.03, 1.56-2.65), spent over twice as long in hospital (IRR, 95% CI: 2.23, 1.67-2.98), and had a higher rate of first-time or incident gastrointestinal disease admissions (hazard ratio, 95% CI: 1.18, 1.08-1.29) when compared with the uninjured cohort, after adjusting for demographic and preexisting health factors. Children who experience a burn injury hospitalization are at increased risk of postburn hospital service use for gastrointestinal diseases when compared with uninjured children.

    Original languageEnglish
    Pages (from-to)125-133
    Number of pages9
    JournalJournal of Burn Care and Research
    Volume38
    Issue number2
    DOIs
    Publication statusPublished - 2017

    Fingerprint

    Gastrointestinal Diseases
    Burns
    Pediatrics
    Western Australia
    Confidence Intervals
    Population
    Incidence
    Wounds and Injuries
    Longitudinal Studies
    Gastrointestinal Tract
    Length of Stay
    Hospitalization
    Demography
    Parturition
    Morbidity
    Health

    Cite this

    @article{c89b0f009d25480e880dd8bdf6af6414,
    title = "Effects of Pediatric Burns on Gastrointestinal Diseases: A Population-Based Study",
    abstract = "The systemic responses triggered by burns have been shown to include effects on the gastrointestinal tract. However, it is not clear if these changes lead to long-term gastrointestinal morbidity in patients with burns. The aim of this study was to assess if pediatric burns are associated with increased hospital use for gastrointestinal diseases after discharge for the initial injury. A population-based longitudinal study was performed using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10,436) between 1980 and 2012, along with a frequency-matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40,819). Crude admission rates and cumulative length of stay for digestive diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios (IRRs) and hazard ratios, respectively. After discharge, the pediatric burn cohort experienced twice the rate of gastrointestinal disease admissions (IRR, 95{\%} confidence interval [CI]: 2.03, 1.56-2.65), spent over twice as long in hospital (IRR, 95{\%} CI: 2.23, 1.67-2.98), and had a higher rate of first-time or incident gastrointestinal disease admissions (hazard ratio, 95{\%} CI: 1.18, 1.08-1.29) when compared with the uninjured cohort, after adjusting for demographic and preexisting health factors. Children who experience a burn injury hospitalization are at increased risk of postburn hospital service use for gastrointestinal diseases when compared with uninjured children.",
    author = "Boyd, {James H.} and Wood, {Fiona M.} and Randall, {Sean M.} and Fear, {Mark W.} and Suzanne Rea and Duke, {Janine M.}",
    year = "2017",
    doi = "10.1097/BCR.0000000000000415",
    language = "English",
    volume = "38",
    pages = "125--133",
    journal = "Journal of Burn Care & Research",
    issn = "1559-047X",
    publisher = "Lippincott Williams & Wilkins",
    number = "2",

    }

    Effects of Pediatric Burns on Gastrointestinal Diseases : A Population-Based Study. / Boyd, James H.; Wood, Fiona M.; Randall, Sean M.; Fear, Mark W.; Rea, Suzanne; Duke, Janine M.

    In: Journal of Burn Care and Research, Vol. 38, No. 2, 2017, p. 125-133.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Effects of Pediatric Burns on Gastrointestinal Diseases

    T2 - A Population-Based Study

    AU - Boyd, James H.

    AU - Wood, Fiona M.

    AU - Randall, Sean M.

    AU - Fear, Mark W.

    AU - Rea, Suzanne

    AU - Duke, Janine M.

    PY - 2017

    Y1 - 2017

    N2 - The systemic responses triggered by burns have been shown to include effects on the gastrointestinal tract. However, it is not clear if these changes lead to long-term gastrointestinal morbidity in patients with burns. The aim of this study was to assess if pediatric burns are associated with increased hospital use for gastrointestinal diseases after discharge for the initial injury. A population-based longitudinal study was performed using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10,436) between 1980 and 2012, along with a frequency-matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40,819). Crude admission rates and cumulative length of stay for digestive diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios (IRRs) and hazard ratios, respectively. After discharge, the pediatric burn cohort experienced twice the rate of gastrointestinal disease admissions (IRR, 95% confidence interval [CI]: 2.03, 1.56-2.65), spent over twice as long in hospital (IRR, 95% CI: 2.23, 1.67-2.98), and had a higher rate of first-time or incident gastrointestinal disease admissions (hazard ratio, 95% CI: 1.18, 1.08-1.29) when compared with the uninjured cohort, after adjusting for demographic and preexisting health factors. Children who experience a burn injury hospitalization are at increased risk of postburn hospital service use for gastrointestinal diseases when compared with uninjured children.

    AB - The systemic responses triggered by burns have been shown to include effects on the gastrointestinal tract. However, it is not clear if these changes lead to long-term gastrointestinal morbidity in patients with burns. The aim of this study was to assess if pediatric burns are associated with increased hospital use for gastrointestinal diseases after discharge for the initial injury. A population-based longitudinal study was performed using linked hospital and death data from Western Australia for children younger than 15 years when hospitalized for a first burn injury (n = 10,436) between 1980 and 2012, along with a frequency-matched noninjury comparison cohort, randomly selected from Western Australia's birth registrations (n = 40,819). Crude admission rates and cumulative length of stay for digestive diseases were calculated. Negative binomial and Cox proportional hazards regression modeling were used to generate incidence rate ratios (IRRs) and hazard ratios, respectively. After discharge, the pediatric burn cohort experienced twice the rate of gastrointestinal disease admissions (IRR, 95% confidence interval [CI]: 2.03, 1.56-2.65), spent over twice as long in hospital (IRR, 95% CI: 2.23, 1.67-2.98), and had a higher rate of first-time or incident gastrointestinal disease admissions (hazard ratio, 95% CI: 1.18, 1.08-1.29) when compared with the uninjured cohort, after adjusting for demographic and preexisting health factors. Children who experience a burn injury hospitalization are at increased risk of postburn hospital service use for gastrointestinal diseases when compared with uninjured children.

    UR - http://www.scopus.com/inward/record.url?scp=85016220969&partnerID=8YFLogxK

    U2 - 10.1097/BCR.0000000000000415

    DO - 10.1097/BCR.0000000000000415

    M3 - Article

    VL - 38

    SP - 125

    EP - 133

    JO - Journal of Burn Care & Research

    JF - Journal of Burn Care & Research

    SN - 1559-047X

    IS - 2

    ER -