Effects of paternal age on oxidative stress and fertility in the human male

Su-Ann Koh

Effects of paternal age on oxidative stress and fertility in the human male

Su-Ann Koh

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated abstract] This thesis reports on a comprehensive study of the relationships between male age, oxidative stress and fertility within the context of assisted reproductive technology (ART). The central hypothesis was that oxidative stress is a significant mechanism through which advanced paternal age influences fertility. Two approaches encompassing three studies made up the project – a) a cohort study using a sperm donor model (Study 1) and b) a cell biology approach utilising fresh (Study 2) and cryopreserved (Study 3) semen samples. The first approach, (Study 1) aimed to determine the clinical relevance of male age on fertility. The influence of paternal age on clinical pregnancy was investigated using a donor insemination cohort where female recipients had no known fertility problems. Analyses were undertaken separately within 2141 insemination cycles involving younger women (

Original language	English
Qualification	Doctor of Philosophy
Publication status	Unpublished - 2013

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title = "Effects of paternal age on oxidative stress and fertility in the human male",

abstract = "[Truncated abstract] This thesis reports on a comprehensive study of the relationships between male age, oxidative stress and fertility within the context of assisted reproductive technology (ART). The central hypothesis was that oxidative stress is a significant mechanism through which advanced paternal age influences fertility. Two approaches encompassing three studies made up the project – a) a cohort study using a sperm donor model (Study 1) and b) a cell biology approach utilising fresh (Study 2) and cryopreserved (Study 3) semen samples. The first approach, (Study 1) aimed to determine the clinical relevance of male age on fertility. The influence of paternal age on clinical pregnancy was investigated using a donor insemination cohort where female recipients had no known fertility problems. Analyses were undertaken separately within 2141 insemination cycles involving younger women (",

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AB - [Truncated abstract] This thesis reports on a comprehensive study of the relationships between male age, oxidative stress and fertility within the context of assisted reproductive technology (ART). The central hypothesis was that oxidative stress is a significant mechanism through which advanced paternal age influences fertility. Two approaches encompassing three studies made up the project – a) a cohort study using a sperm donor model (Study 1) and b) a cell biology approach utilising fresh (Study 2) and cryopreserved (Study 3) semen samples. The first approach, (Study 1) aimed to determine the clinical relevance of male age on fertility. The influence of paternal age on clinical pregnancy was investigated using a donor insemination cohort where female recipients had no known fertility problems. Analyses were undertaken separately within 2141 insemination cycles involving younger women (

KW - Male age

KW - Human fertility

KW - Sperm quality

KW - Donor insemination

KW - Oxidative stress

KW - DNA damage

KW - Sperm cryopreservation

KW - Assisted reproductive technology

M3 - Doctoral Thesis

ER -

Effects of paternal age on oxidative stress and fertility in the human male

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