Effects of oral contraceptives on vascular endothelium in premenopausal women

Stefan John, Johannes Jacobi, Markus P. Schlaich, Christian Delles, Roland E. Schmieder

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

OBJECTIVE: Premenopausal women are protected against atherosclerosis by high plasma estrogen levels, which have been suggested to augment endothelial nitric oxide synthesis and to improve endothelial function. In contrast, premenopausal use of oral contraceptives is associated with an increased cardiovascular risk. We investigated the influence of oral contraception on endothelial function. STUDY DESIGN: Sixteen healthy premenopausal women with a mean age (±SD) of 27 ± 3 years, 8 of whom used oral contraceptives and 8 of whom did not, were examined in a case-control study. Forearm plethysmography was used to measure changes of forearm blood flow in response to intra-arterial infusion of increasing doses of acetylcholine, sodium nitroprusside, and N(G)-monomethyl-L-arginine. RESULTS: Endothelium-dependent vasodilatation (change from baseline after acetylcholine 48 μg/min) was similar between women with (828% ± 137%) and without oral contraception (701% ± 114%; P not significant), as was endothelium-independent vasodilatation (change from baseline after sodium nitroprusside 3200 ng/min, 271% ± 38% vs 289% ± 23%; P not significant). In contrast, inhibition of nitric oxide synthase with N(G)-monomethyl-L-arginine induced a significantly more marked decrease in blood flow among women with oral contraception than among those without at all dosages (change from baseline after 4-μmol/min N(G)-monomethyl-L-arginine, -26% ± 3% vs -14% ± 5%; P = .009 by analysis of variance). CONCLUSION: Stimulated nitric oxide bioavailability remained unaffected in a group of premenopausal women receiving oral contraceptives. In contrast, basal nitric oxide production and release appeared to be enhanced by oral contraceptive use.

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalAmerican Journal of Obstetrics and Gynecology
Volume183
Issue number1
DOIs
Publication statusPublished - 2000
Externally publishedYes

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