Effects of nimodipine and/or haloperidol on the expression of conditioned locomotion and sensitization to cocaine in rats

The development of classical conditioning of cocaine's locomotor effects can be dissociated from the development of sensitization to cocaine by co-administration of haloperidol, a dopamine D₂-like receptor antagonist, and nimodipine, an L-type calcium channel antagonist. The effects of these agents on the expression of conditioning and sensitization are described in the present report. Rats were given injections of vehicle or cocaine (10 mg/kg, IP) for 10 days before placement in a specific context in which locomotor activity was recorded. Neither haloperidol (0.05 mg/kg, IP) nor nimodipine (10 mg/kg, SC) influenced the expression of classical conditioning of cocaine's locomotor effects to the situational context on a subsequent cocaine-free test. Combined treatment of rats with both drugs did block classical conditioning with cocaine. Nimodipine, but not haloperidol, blocked the expression of behavioural sensitization to cocaine after a cocaine challenge. It is concluded that the expression of cocaine-induced classical conditioning can be pharmacologically dissociated from the expression of behavioural sensitization to cocaine. Furthermore, the effects of nimodipine and haloperidol on the expression of conditioning and sensitization are different from their effects on the development of these phenomena.