Significant genetic variability exists between strains of murine cytomegalovirus (MCMV), which can have profound impacts on the function of immunomodulatory genes. Analysis of a panel of MCMV strains revealed variation in capacity to downmodulate MHC I, which was associated with m04 genotype. Deletion of m152enhanced duration of viral persistence and viral shedding into saliva, and attenuated acute viral replication. These were restored to wild-type when NKG2D was blocked in vivo. These data demonstrate that virus modulation of host immunity is complex, and that variation or deletion of one of several immunomodulatory genes can perturb the network with unexpected consequences.
|Qualification||Doctor of Philosophy|
|Award date||13 Nov 2018|
|Publication status||Unpublished - 2018|