TY - JOUR
T1 - Effects of Moxonidine and Low-Calorie Diet
T2 - Cardiometabolic Benefits from Combination of Both Therapies
AU - Lambert, Elisabeth A.
AU - Sari, Carolina I.
AU - Eikelis, Nina
AU - Phillips, Sarah E.
AU - Grima, Mariee
AU - Straznicky, Nora E.
AU - Dixon, John B.
AU - Esler, Murray
AU - Schlaich, Markus P.
AU - Head, Geoffrey A.
AU - Lambert, Gavin W.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - Objective: Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of a centrally acting sympatholytic agent, the effects of a weight loss (WL) program using a low-calorie diet, and the effects of a combination of both. Methods: Young (18-30 years) male subjects with overweight (BMI > 25 kg/m2) were allocated to a WL program (n = 10), a moxonidine treatment course (M; n = 10, 0.4 mg/d), a combination of both (WL + M; n = 11), or to a control (C) group (n = 6) for 6 months. Muscle sympathetic nerve activity (MSNA), endothelial function, renal function (Cockcroft-Gault formula), and the metabolic profile were assessed before and after intervention. Results: WL occurred in the WL and WL + M groups (−7.6 ± 1.9 kg, P < 0.001 in both). MSNA and systolic blood pressure decreased similarly in the WL, M, and WL + M groups (by ∼10 bursts/min, P < 0.001, and by ∼9 mm Hg, P < 0.05). All other parameters for the WL, C, and M groups remained unchanged. In the WL + M group, decreased total cholesterol (−0.78 ± 0.23 mmol/L, P < 0.001), decreased low-density lipoprotein cholesterol (−0.49 ± 0.16 mmol/L, P < 0.01), decreased insulin (−6.5 ± 2.8 mmol/L, P < 0.05), and attenuated glomerular hyperfiltration (−19 ± 5 mL/min, P < 0.01) occurred. Conclusions: The combination of moxonidine with a WL program has beneficial effects on aspects of the metabolic profile and end organ damage in young males with overweight.
AB - Objective: Because sympathetic nervous system activity plays a detrimental role in metabolic and cardiovascular health, this study compared the effects of a centrally acting sympatholytic agent, the effects of a weight loss (WL) program using a low-calorie diet, and the effects of a combination of both. Methods: Young (18-30 years) male subjects with overweight (BMI > 25 kg/m2) were allocated to a WL program (n = 10), a moxonidine treatment course (M; n = 10, 0.4 mg/d), a combination of both (WL + M; n = 11), or to a control (C) group (n = 6) for 6 months. Muscle sympathetic nerve activity (MSNA), endothelial function, renal function (Cockcroft-Gault formula), and the metabolic profile were assessed before and after intervention. Results: WL occurred in the WL and WL + M groups (−7.6 ± 1.9 kg, P < 0.001 in both). MSNA and systolic blood pressure decreased similarly in the WL, M, and WL + M groups (by ∼10 bursts/min, P < 0.001, and by ∼9 mm Hg, P < 0.05). All other parameters for the WL, C, and M groups remained unchanged. In the WL + M group, decreased total cholesterol (−0.78 ± 0.23 mmol/L, P < 0.001), decreased low-density lipoprotein cholesterol (−0.49 ± 0.16 mmol/L, P < 0.01), decreased insulin (−6.5 ± 2.8 mmol/L, P < 0.05), and attenuated glomerular hyperfiltration (−19 ± 5 mL/min, P < 0.01) occurred. Conclusions: The combination of moxonidine with a WL program has beneficial effects on aspects of the metabolic profile and end organ damage in young males with overweight.
UR - http://www.scopus.com/inward/record.url?scp=85028589210&partnerID=8YFLogxK
U2 - 10.1002/oby.21962
DO - 10.1002/oby.21962
M3 - Article
C2 - 28865109
AN - SCOPUS:85028589210
SN - 1930-7381
VL - 25
SP - 1894
EP - 1902
JO - Obesity
JF - Obesity
IS - 11
ER -
