Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes

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Abstract

Aims Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterize the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. Method An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation

Original languageEnglish
Pages (from-to)147-159
Number of pages13
JournalBritish Journal of Clinical Pharmacology
Volume85
Issue number1
DOIs
Publication statusPublished - Jan 2019

Cite this

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title = "Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis: a pilot study incorporating clinical outcomes",
abstract = "Aims Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterize the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. Method An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation",
keywords = "late-onset sepsis, lisofylline, necrotizing enterocolitis, pentoxifylline, population pharmacokinetics, preterm infant, INFLAMMATION, INJURY, BLOOD",
author = "Sam Salman and Julie Hibbert and Madhu Page-Sharp and Laurens Manning and Karen Simmer and Doherty, {Dorota A.} and Sanjay Patole and Batty, {Kevin T.} and Tobias Strunk",
year = "2019",
month = "1",
doi = "10.1111/bcp.13775",
language = "English",
volume = "85",
pages = "147--159",
journal = "British Journal Clinical Pharmacology",
issn = "0306-5251",
publisher = "John Wiley & Sons",
number = "1",

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TY - JOUR

T1 - Effects of maturation and size on population pharmacokinetics of pentoxifylline and its metabolites in very preterm infants with suspected late-onset sepsis or necrotizing enterocolitis

T2 - a pilot study incorporating clinical outcomes

AU - Salman, Sam

AU - Hibbert, Julie

AU - Page-Sharp, Madhu

AU - Manning, Laurens

AU - Simmer, Karen

AU - Doherty, Dorota A.

AU - Patole, Sanjay

AU - Batty, Kevin T.

AU - Strunk, Tobias

PY - 2019/1

Y1 - 2019/1

N2 - Aims Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterize the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. Method An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation

AB - Aims Infection-induced inflammation is associated with adverse long-term outcomes in preterm infants. Pentoxifylline (PTX) is a candidate for adjunct immunomodulatory therapy in preterm infants with late-onset sepsis (LOS) and necrotizing enterocolitis (NEC), but pharmacokinetic data in this population are extremely limited. This study aims to characterize the pharmacokinetic properties of intravenous PTX and its metabolites in preterm infants. Method An open label pilot clinical study of intravenous PTX as an adjunct therapy in preterm infants (gestation

KW - late-onset sepsis

KW - lisofylline

KW - necrotizing enterocolitis

KW - pentoxifylline

KW - population pharmacokinetics

KW - preterm infant

KW - INFLAMMATION

KW - INJURY

KW - BLOOD

U2 - 10.1111/bcp.13775

DO - 10.1111/bcp.13775

M3 - Article

VL - 85

SP - 147

EP - 159

JO - British Journal Clinical Pharmacology

JF - British Journal Clinical Pharmacology

SN - 0306-5251

IS - 1

ER -