Effects of low intensity repetitive transcranial stimulation (rTMS) in humans and a review of glial responses to rTMS

Matthew French

doi:10.26182/ea10-kw88

Effects of low intensity repetitive transcranial stimulation (rTMS) in humans and a review of glial responses to rTMS

Matthew French

Research output: Thesis › Master's Thesis

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Abstract

Repetitive transcranial magnetic stimulation (rTMS) represents a novel way to alter the form and function of CNS cells, both in animals and humans. In my first aim, I investigated whether low intensity rTMS altered a measure of cortical excitability, motor evoked potentials, and found a significant change. This finding provided the first evidence supporting LI-rTMS effects in humans, and mirrors effects shown in animal models. For my second aim, I reviewed key rTMS induced changes to the form and function of the major glial cell types in order to identify knowledge gaps in preclinical rTMS research.

Original language	English
Qualification	Masters
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Rodger, Jennifer, Supervisor Hodgetts, Stuart, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	13 Sept 2024
DOIs	https://doi.org/10.26182/ea10-kw88
Publication status	Unpublished - 2024

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10.26182/ea10-kw88

THESIS - MASTER OF PHILOSOPHY - FRENCH Matthew Charles - 2024
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title = "Effects of low intensity repetitive transcranial stimulation (rTMS) in humans and a review of glial responses to rTMS",

abstract = "Repetitive transcranial magnetic stimulation (rTMS) represents a novel way to alter the form and function of CNS cells, both in animals and humans. In my first aim, I investigated whether low intensity rTMS altered a measure of cortical excitability, motor evoked potentials, and found a significant change. This finding provided the first evidence supporting LI-rTMS effects in humans, and mirrors effects shown in animal models. For my second aim, I reviewed key rTMS induced changes to the form and function of the major glial cell types in order to identify knowledge gaps in preclinical rTMS research.",

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AB - Repetitive transcranial magnetic stimulation (rTMS) represents a novel way to alter the form and function of CNS cells, both in animals and humans. In my first aim, I investigated whether low intensity rTMS altered a measure of cortical excitability, motor evoked potentials, and found a significant change. This finding provided the first evidence supporting LI-rTMS effects in humans, and mirrors effects shown in animal models. For my second aim, I reviewed key rTMS induced changes to the form and function of the major glial cell types in order to identify knowledge gaps in preclinical rTMS research.

KW - rTMS

KW - Glia

KW - excitability

U2 - 10.26182/ea10-kw88

DO - 10.26182/ea10-kw88

M3 - Master's Thesis

ER -

Effects of low intensity repetitive transcranial stimulation (rTMS) in humans and a review of glial responses to rTMS

Abstract

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