Effects of ischaemic conditioning on major clinical outcomes in people undergoing invasive procedures: Systematic review and meta-analysis

Objective: To summarise the benefits and harms of ischaemic conditioning on major clinical outcomes in various settings. Design: Systematic review and meta-analysis. Data sources: Medline, Embase, Cochrane databases, and International Clinical Trials Registry platform from inception through October 2015. Study selection: All randomised controlled comparisons of the effect of ischaemic conditioning on clinical outcomes were included. Data extraction: Two authors independently extracted data from individual reports. Reports of multiple intervention arms were treated as separate trials. Random effects models were used to calculate summary estimates for all cause mortality and other pre-specified clinical outcomes. All cause mortality and secondary outcomes with P