Effects of hypoglycemia on human brain activation measured with fMRI.

A.W. Anderson; R.A. Heptulla; N. Driesen; D. Flanagan; P.A. Goldberg; Timothy Jones; F. Rife; H. Sarofin; W. Tamborlane; R. Sherwin; J.C. Gore

doi:10.1016/j.mri.2006.03.013

Effects of hypoglycemia on human brain activation measured with fMRI.

A.W. Anderson, R.A. Heptulla, N. Driesen, D. Flanagan, P.A. Goldberg, Timothy Jones, F. Rife, H. Sarofin, W. Tamborlane, R. Sherwin, J.C. Gore

UWA Centre for Child Health Research (affiliated with the Telethon Kids Institute)

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory Stimulation oil brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast. which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 divided by 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects; the fractional signal change was reduced by 28 divided by 12% (P < .05). These changes were were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain. (C) 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	693-97
Journal	Magnetic Resonance Imaging
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.mri.2006.03.013
Publication status	Published - 2006

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title = "Effects of hypoglycemia on human brain activation measured with fMRI.",

abstract = "Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory Stimulation oil brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast. which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 divided by 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects; the fractional signal change was reduced by 28 divided by 12% (P < .05). These changes were were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain. (C) 2006 Elsevier Inc. All rights reserved.",

author = "A.W. Anderson and R.A. Heptulla and N. Driesen and D. Flanagan and P.A. Goldberg and Timothy Jones and F. Rife and H. Sarofin and W. Tamborlane and R. Sherwin and J.C. Gore",

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T1 - Effects of hypoglycemia on human brain activation measured with fMRI.

AU - Anderson, A.W.

AU - Heptulla, R.A.

AU - Driesen, N.

AU - Flanagan, D.

AU - Goldberg, P.A.

AU - Jones, Timothy

AU - Rife, F.

AU - Sarofin, H.

AU - Tamborlane, W.

AU - Sherwin, R.

AU - Gore, J.C.

PY - 2006

Y1 - 2006

N2 - Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory Stimulation oil brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast. which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 divided by 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects; the fractional signal change was reduced by 28 divided by 12% (P < .05). These changes were were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain. (C) 2006 Elsevier Inc. All rights reserved.

AB - Functional magnetic resonance imaging (fMRI) was used to measure the effects of acute hypoglycemia caused by passive sensory Stimulation oil brain activation. Visual stimulation was used to generate blood-oxygen-level-dependent (BOLD) contrast. which was monitored during hyperinsulinemic hypoglycemic and euglycemic clamp studies. Hypoglycemia (50 divided by 1 mg glucose/dl) decreased the fMRI signal relative to euglycemia in 10 healthy human subjects; the fractional signal change was reduced by 28 divided by 12% (P < .05). These changes were were reversed when euglycemia was restored. These data provide a basis of comparison for studies that quantify hypoglycemia-related changes in fMRI activity during cognitive tasks based on visual stimuli and demonstrate that variations in blood glucose levels may modulate BOLD signals in the healthy brain. (C) 2006 Elsevier Inc. All rights reserved.

U2 - 10.1016/j.mri.2006.03.013

DO - 10.1016/j.mri.2006.03.013

M3 - Article

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VL - 24

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EP - 697

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 6

ER -

Effects of hypoglycemia on human brain activation measured with fMRI.

Abstract

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