TY - JOUR
T1 - Effects of follicle-stimulating hormone on fat metabolism and cognitive impairment in women during menopause
AU - Mao, Liwei
AU - Wang, Lian
AU - Bennett, Samuel
AU - Xu, Jiake
AU - Zou, Jun
N1 - Funding Information:
This work was supported by 2021 Capacity Building of Shanghai Universities (21010503600); National Natural Science Foundation of China (81871835); Shanghai Frontiers Science Research Base of Exercise and Metabolic Health; Shanghai Key Laboratory of Human Performance (Shanghai University of Sport) (No. 11DZ2261100).
Publisher Copyright:
Copyright © 2022 Mao, Wang, Bennett, Xu and Zou.
PY - 2022/12/5
Y1 - 2022/12/5
N2 - Lipid metabolism disorder is a common pathological manifestation of menopausal women, and is also an important risk factor for many diseases at this stage of life. Epidemiological studies have shown that high levels of follicle-stimulating hormone (FSH) in menopausal women are closely associated with changes in body composition, central obesity, and cognitive decline. Exogenous FSH causes growth and proliferation of adipose, whereas blockage of the FSH signaling pathway leads to decline in adipose. Mechanistically, FSH, FSH receptor (FSHR), G protein coupling, gene mutation and other pathways are involved in adipogenesis and cognitive impairment. Here, we review the critical role and potential interactions of FSH in adipogenesis and cognitive impairment in menopausal women. Further understanding of the exact mechanisms of FSH aggravating obesity and cognitive impairment may provide a new perspective for promoting healthy aging in menopausal women.
AB - Lipid metabolism disorder is a common pathological manifestation of menopausal women, and is also an important risk factor for many diseases at this stage of life. Epidemiological studies have shown that high levels of follicle-stimulating hormone (FSH) in menopausal women are closely associated with changes in body composition, central obesity, and cognitive decline. Exogenous FSH causes growth and proliferation of adipose, whereas blockage of the FSH signaling pathway leads to decline in adipose. Mechanistically, FSH, FSH receptor (FSHR), G protein coupling, gene mutation and other pathways are involved in adipogenesis and cognitive impairment. Here, we review the critical role and potential interactions of FSH in adipogenesis and cognitive impairment in menopausal women. Further understanding of the exact mechanisms of FSH aggravating obesity and cognitive impairment may provide a new perspective for promoting healthy aging in menopausal women.
KW - adipogenesis
KW - Alzheimer’s disease
KW - cognitive impairment
KW - follicle-stimulating hormone
KW - menopausal women
UR - http://www.scopus.com/inward/record.url?scp=85144195550&partnerID=8YFLogxK
U2 - 10.3389/fphys.2022.1043237
DO - 10.3389/fphys.2022.1043237
M3 - Review article
C2 - 36545281
AN - SCOPUS:85144195550
VL - 13
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 1043237
ER -