Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial

S. Ursoniu, Amirhossein Sahebkar, F. Andrica, C. Serban, M. Banach

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    © 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.Background & aims: Many experimental and clinical trials suggested that flaxseed might be a potent antihypertensive, but the evidences concerning the effects of flaxseed supplements on blood pressure (BP) has not been fully conclusive. We aimed to assess the impact of the effects of flaxseed supplements on blood pressure through systematic review of literature and meta-analysis of available randomized controlled trials (RCTs). Methods: The literature search included PUBMED, Cochrane Library, Scopus, and EMBASE up to February 2015 to identify RCTs investigating the effect of flaxseed supplements on plasma blood pressure. Effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI). Results: 15 trials (comprising 19 treatment arms) with 1302 participants were included in this meta-analysis. Random-effects meta-analysis suggested significant reductions in both systolic BP (SBP) (WMD: -2.85 mmHg, 95%CI: -5.37 to -0.33, p = 0.027) and diastolic BP (DBP) (WMD: -2.39 mmHg, 95%CI: -3.78 to -0.99, p = 0.001) following supplementation with flaxseed products. When the studies were stratified according to their duration, there was a greater effect on both SBP and DBP in the subset of trials with ≥12 weeks of duration (WMD: -3.10 mmHg, 95%CI: -6.46 to 0.27, p = 0.072 and -2.62 mmHg, 95%CI: -4.39 to -0.86, p = 0.003, respectively) vs the subset lasting
    Original languageEnglish
    Pages (from-to)615-625
    JournalClinical Nutrition
    Volume35
    Issue number3
    DOIs
    Publication statusPublished - 2016

    Fingerprint Dive into the research topics of 'Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial'. Together they form a unique fingerprint.

  • Cite this