Effects of exercise on hepcidin response and iron metabolism during recovery

Peter Peeling, Brian Dawson, C. Goodman, Grant Landers, E.T. Wiegerinck, D.W. Swinkels, Debbie Trinder

    Research output: Contribution to journalArticle

    71 Citations (Scopus)

    Abstract

    Urinary hepcidin, inflammation, and iron metabolism were examined during the 24 hr after exercise. Eight moderately trained athletes (6 men, 2 women) completed a 60-min running trial (15-min warm-up at 75–80% HRpeak + 45 min at 85–90% HRpeak) and a 60-min trial of seated rest in a randomized, crossover design. Venous blood and urine samples were collected pretrial, immediately posttrial, and at 3, 6, and 24 hr posttrial. Samples were analyzed for interleukin-6 (IL-6), C-reactive protein (CRP), serum iron, serum ferritin, and urinary hepcidin. The immediate postrun levels of IL-6 and 24-hr postrun levels of CRP were significantly increased from baseline (6.9 and 2.6 times greater, respectively) and when compared with the rest trial (p ≤ .05). Hepcidin levels in the run trial after 3, 6, and 24 hr of recovery were significantly greater (1.7–3.1 times) than the pre- and immediate postrun levels (p ≤ .05). This outcome was consistent in all participants, despite marked variation in the magnitude of rise. In addition, the 3-hr postrun levels of hepcidin were significantly greater than at 3 hr in the rest trial (3.0 times greater, p ≤ .05). Hepcidin levels continued to increase at 6 hr postrun but failed to significantly differ from the rest trial (p = .071), possibly because of diurnal influence. Finally, serum iron levels were significantly increased immediately postrun (1.3 times, p ≤ .05). The authors concluded that high-intensity exercise was responsible for a significant increase in hepcidin levels subsequent to a significant increase in IL-6 and serum iron.
    Original languageEnglish
    Pages (from-to)583-597
    JournalInternational Journal of Sport Nutrition & Exercise Metabolism
    Volume19
    Issue number6
    Publication statusPublished - 2009

    Fingerprint

    Hepcidins
    exercise
    Iron
    Exercise
    iron
    blood serum
    metabolism
    interleukin-6
    Interleukin-6
    C-reactive protein
    Serum
    C-Reactive Protein
    athletes
    ferritin
    Ferritins
    Running
    Athletes
    Cross-Over Studies
    hepcidin
    urine

    Cite this

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    title = "Effects of exercise on hepcidin response and iron metabolism during recovery",
    abstract = "Urinary hepcidin, inflammation, and iron metabolism were examined during the 24 hr after exercise. Eight moderately trained athletes (6 men, 2 women) completed a 60-min running trial (15-min warm-up at 75–80{\%} HRpeak + 45 min at 85–90{\%} HRpeak) and a 60-min trial of seated rest in a randomized, crossover design. Venous blood and urine samples were collected pretrial, immediately posttrial, and at 3, 6, and 24 hr posttrial. Samples were analyzed for interleukin-6 (IL-6), C-reactive protein (CRP), serum iron, serum ferritin, and urinary hepcidin. The immediate postrun levels of IL-6 and 24-hr postrun levels of CRP were significantly increased from baseline (6.9 and 2.6 times greater, respectively) and when compared with the rest trial (p ≤ .05). Hepcidin levels in the run trial after 3, 6, and 24 hr of recovery were significantly greater (1.7–3.1 times) than the pre- and immediate postrun levels (p ≤ .05). This outcome was consistent in all participants, despite marked variation in the magnitude of rise. In addition, the 3-hr postrun levels of hepcidin were significantly greater than at 3 hr in the rest trial (3.0 times greater, p ≤ .05). Hepcidin levels continued to increase at 6 hr postrun but failed to significantly differ from the rest trial (p = .071), possibly because of diurnal influence. Finally, serum iron levels were significantly increased immediately postrun (1.3 times, p ≤ .05). The authors concluded that high-intensity exercise was responsible for a significant increase in hepcidin levels subsequent to a significant increase in IL-6 and serum iron.",
    author = "Peter Peeling and Brian Dawson and C. Goodman and Grant Landers and E.T. Wiegerinck and D.W. Swinkels and Debbie Trinder",
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    language = "English",
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    Effects of exercise on hepcidin response and iron metabolism during recovery. / Peeling, Peter; Dawson, Brian; Goodman, C.; Landers, Grant; Wiegerinck, E.T.; Swinkels, D.W.; Trinder, Debbie.

    In: International Journal of Sport Nutrition & Exercise Metabolism, Vol. 19, No. 6, 2009, p. 583-597.

    Research output: Contribution to journalArticle

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    T1 - Effects of exercise on hepcidin response and iron metabolism during recovery

    AU - Peeling, Peter

    AU - Dawson, Brian

    AU - Goodman, C.

    AU - Landers, Grant

    AU - Wiegerinck, E.T.

    AU - Swinkels, D.W.

    AU - Trinder, Debbie

    PY - 2009

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    AB - Urinary hepcidin, inflammation, and iron metabolism were examined during the 24 hr after exercise. Eight moderately trained athletes (6 men, 2 women) completed a 60-min running trial (15-min warm-up at 75–80% HRpeak + 45 min at 85–90% HRpeak) and a 60-min trial of seated rest in a randomized, crossover design. Venous blood and urine samples were collected pretrial, immediately posttrial, and at 3, 6, and 24 hr posttrial. Samples were analyzed for interleukin-6 (IL-6), C-reactive protein (CRP), serum iron, serum ferritin, and urinary hepcidin. The immediate postrun levels of IL-6 and 24-hr postrun levels of CRP were significantly increased from baseline (6.9 and 2.6 times greater, respectively) and when compared with the rest trial (p ≤ .05). Hepcidin levels in the run trial after 3, 6, and 24 hr of recovery were significantly greater (1.7–3.1 times) than the pre- and immediate postrun levels (p ≤ .05). This outcome was consistent in all participants, despite marked variation in the magnitude of rise. In addition, the 3-hr postrun levels of hepcidin were significantly greater than at 3 hr in the rest trial (3.0 times greater, p ≤ .05). Hepcidin levels continued to increase at 6 hr postrun but failed to significantly differ from the rest trial (p = .071), possibly because of diurnal influence. Finally, serum iron levels were significantly increased immediately postrun (1.3 times, p ≤ .05). The authors concluded that high-intensity exercise was responsible for a significant increase in hepcidin levels subsequent to a significant increase in IL-6 and serum iron.

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    JO - International Journal of Sport Nutrition & Exercise Metabolism

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