Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women

Richard Prince, Nicole Austin, A. Devine, Ian Dick, David Bruce, Kun Zhu

Research output: Contribution to journalArticle

138 Citations (Scopus)

Abstract

Background: Ergocalciferol (vitamin D-2) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling.Methods: A 1-year population-based, double-blind, randomized controlled trial of 302 community-dwelling ambulant older women aged 70 to 90 years living in Perth, Australia (latitude, 32 degrees S), with a serum 25-hydroxy-vitamin D concentration of less than 24.0 ng/mL and a history of falling in the previous year. Participants were randomized to receive ergocalciferol, 1000 IU/d, or identical placebo (hereinafter, ergocalciferol and control groups, respectively). Both groups received calcium citrate, 1000 mg/d. Fall data were collected every 6 weeks.Results: Ergocalciferol therapy reduced the risk of having at least I fall over I year after adjustment for baseline height, which was significantly different between the 2 groups (ergocalciferol group, 53.0%; control group, 62.9%; odds ratio [OR], 0.61; 95% confidence interval [CI], 0.37-0.99). When those who fell were grouped by the season of first fall or the number of falls they had, ergocalciferol treatment reduced the risk of having the first fall in winter and spring (ergocalciferol group, 25.2%; control group, 35.8%; OR, 0.55; 95% CI, 0.32-0.96) but not in summer and autumn, and reduced the risk of having 1 fall (ergocalciferol group, 21.2%; control group, 33.8%; OR, 0.50; 95% CI, 0.28-0.88) but not multiple falls.Conclusion: Patients with a history of falling and vitamin D insufficiency living in sunny climates benefit from ergocalciferol supplementation in addition to calcium, which is associated with a 19% reduction in the relative risk of falling, mostly in winter.
Original languageEnglish
Pages (from-to)103-108
JournalArchives of Internal Medicine
Volume168
Issue number1
DOIs
Publication statusPublished - 2008

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Ergocalciferols
Calcium
Accidental Falls
Calcium Citrate
Control Groups
Odds Ratio
Confidence Intervals
Climate
Vitamin D
Independent Living
Randomized Controlled Trials
Placebos

Cite this

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title = "Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women",
abstract = "Background: Ergocalciferol (vitamin D-2) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling.Methods: A 1-year population-based, double-blind, randomized controlled trial of 302 community-dwelling ambulant older women aged 70 to 90 years living in Perth, Australia (latitude, 32 degrees S), with a serum 25-hydroxy-vitamin D concentration of less than 24.0 ng/mL and a history of falling in the previous year. Participants were randomized to receive ergocalciferol, 1000 IU/d, or identical placebo (hereinafter, ergocalciferol and control groups, respectively). Both groups received calcium citrate, 1000 mg/d. Fall data were collected every 6 weeks.Results: Ergocalciferol therapy reduced the risk of having at least I fall over I year after adjustment for baseline height, which was significantly different between the 2 groups (ergocalciferol group, 53.0{\%}; control group, 62.9{\%}; odds ratio [OR], 0.61; 95{\%} confidence interval [CI], 0.37-0.99). When those who fell were grouped by the season of first fall or the number of falls they had, ergocalciferol treatment reduced the risk of having the first fall in winter and spring (ergocalciferol group, 25.2{\%}; control group, 35.8{\%}; OR, 0.55; 95{\%} CI, 0.32-0.96) but not in summer and autumn, and reduced the risk of having 1 fall (ergocalciferol group, 21.2{\%}; control group, 33.8{\%}; OR, 0.50; 95{\%} CI, 0.28-0.88) but not multiple falls.Conclusion: Patients with a history of falling and vitamin D insufficiency living in sunny climates benefit from ergocalciferol supplementation in addition to calcium, which is associated with a 19{\%} reduction in the relative risk of falling, mostly in winter.",
author = "Richard Prince and Nicole Austin and A. Devine and Ian Dick and David Bruce and Kun Zhu",
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Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women. / Prince, Richard; Austin, Nicole; Devine, A.; Dick, Ian; Bruce, David; Zhu, Kun.

In: Archives of Internal Medicine, Vol. 168, No. 1, 2008, p. 103-108.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Ergocalciferol Added to Calcium on the Risk of Falls in Elderly High-Risk Women

AU - Prince, Richard

AU - Austin, Nicole

AU - Devine, A.

AU - Dick, Ian

AU - Bruce, David

AU - Zhu, Kun

PY - 2008

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N2 - Background: Ergocalciferol (vitamin D-2) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling.Methods: A 1-year population-based, double-blind, randomized controlled trial of 302 community-dwelling ambulant older women aged 70 to 90 years living in Perth, Australia (latitude, 32 degrees S), with a serum 25-hydroxy-vitamin D concentration of less than 24.0 ng/mL and a history of falling in the previous year. Participants were randomized to receive ergocalciferol, 1000 IU/d, or identical placebo (hereinafter, ergocalciferol and control groups, respectively). Both groups received calcium citrate, 1000 mg/d. Fall data were collected every 6 weeks.Results: Ergocalciferol therapy reduced the risk of having at least I fall over I year after adjustment for baseline height, which was significantly different between the 2 groups (ergocalciferol group, 53.0%; control group, 62.9%; odds ratio [OR], 0.61; 95% confidence interval [CI], 0.37-0.99). When those who fell were grouped by the season of first fall or the number of falls they had, ergocalciferol treatment reduced the risk of having the first fall in winter and spring (ergocalciferol group, 25.2%; control group, 35.8%; OR, 0.55; 95% CI, 0.32-0.96) but not in summer and autumn, and reduced the risk of having 1 fall (ergocalciferol group, 21.2%; control group, 33.8%; OR, 0.50; 95% CI, 0.28-0.88) but not multiple falls.Conclusion: Patients with a history of falling and vitamin D insufficiency living in sunny climates benefit from ergocalciferol supplementation in addition to calcium, which is associated with a 19% reduction in the relative risk of falling, mostly in winter.

AB - Background: Ergocalciferol (vitamin D-2) supplementation plays a role in fall prevention, but the effect in patients living in the community in sunny climates remains uncertain. We evaluated the effect of ergocalciferol and calcium citrate supplementation compared with calcium alone on the risk of falls in older women at high risk of falling.Methods: A 1-year population-based, double-blind, randomized controlled trial of 302 community-dwelling ambulant older women aged 70 to 90 years living in Perth, Australia (latitude, 32 degrees S), with a serum 25-hydroxy-vitamin D concentration of less than 24.0 ng/mL and a history of falling in the previous year. Participants were randomized to receive ergocalciferol, 1000 IU/d, or identical placebo (hereinafter, ergocalciferol and control groups, respectively). Both groups received calcium citrate, 1000 mg/d. Fall data were collected every 6 weeks.Results: Ergocalciferol therapy reduced the risk of having at least I fall over I year after adjustment for baseline height, which was significantly different between the 2 groups (ergocalciferol group, 53.0%; control group, 62.9%; odds ratio [OR], 0.61; 95% confidence interval [CI], 0.37-0.99). When those who fell were grouped by the season of first fall or the number of falls they had, ergocalciferol treatment reduced the risk of having the first fall in winter and spring (ergocalciferol group, 25.2%; control group, 35.8%; OR, 0.55; 95% CI, 0.32-0.96) but not in summer and autumn, and reduced the risk of having 1 fall (ergocalciferol group, 21.2%; control group, 33.8%; OR, 0.50; 95% CI, 0.28-0.88) but not multiple falls.Conclusion: Patients with a history of falling and vitamin D insufficiency living in sunny climates benefit from ergocalciferol supplementation in addition to calcium, which is associated with a 19% reduction in the relative risk of falling, mostly in winter.

U2 - 10.1001/archinternmed.2007.31

DO - 10.1001/archinternmed.2007.31

M3 - Article

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JO - Archives of Internal Medicine

JF - Archives of Internal Medicine

SN - 0003-9926

IS - 1

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