Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy: A Year-long Randomised Controlled Trial

Dennis R. Taaffe, Robert U. Newton, Nigel Spry, David Joseph, Suzanne K. Chambers, Robert A. Gardiner, Brad A. Wall, Prue Cormie, Kate A. Bolam, Daniel A. Galvão

Research output: Contribution to journalArticle

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Abstract

Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo. Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p trend

Original languageEnglish
Pages (from-to)293-299
JournalEuropean Urology
Volume72
Issue number2
DOIs
Publication statusPublished - Aug 2017

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Androgens
Fatigue
Prostatic Neoplasms
Randomized Controlled Trials
Exercise
Therapeutics
Resistance Training
Musculoskeletal System
Pamphlets
Cardiovascular System
Prescriptions
Analysis of Variance
Quality of Life

Cite this

Taaffe, Dennis R. ; Newton, Robert U. ; Spry, Nigel ; Joseph, David ; Chambers, Suzanne K. ; Gardiner, Robert A. ; Wall, Brad A. ; Cormie, Prue ; Bolam, Kate A. ; Galvão, Daniel A. / Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy : A Year-long Randomised Controlled Trial. In: European Urology. 2017 ; Vol. 72, No. 2. pp. 293-299.
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abstract = "Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo. Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p trend",
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Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy : A Year-long Randomised Controlled Trial. / Taaffe, Dennis R.; Newton, Robert U.; Spry, Nigel; Joseph, David; Chambers, Suzanne K.; Gardiner, Robert A.; Wall, Brad A.; Cormie, Prue; Bolam, Kate A.; Galvão, Daniel A.

In: European Urology, Vol. 72, No. 2, 08.2017, p. 293-299.

Research output: Contribution to journalArticle

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T1 - Effects of Different Exercise Modalities on Fatigue in Prostate Cancer Patients Undergoing Androgen Deprivation Therapy

T2 - A Year-long Randomised Controlled Trial

AU - Taaffe, Dennis R.

AU - Newton, Robert U.

AU - Spry, Nigel

AU - Joseph, David

AU - Chambers, Suzanne K.

AU - Gardiner, Robert A.

AU - Wall, Brad A.

AU - Cormie, Prue

AU - Bolam, Kate A.

AU - Galvão, Daniel A.

PY - 2017/8

Y1 - 2017/8

N2 - Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo. Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p trend

AB - Background: Physical exercise mitigates fatigue during androgen deprivation therapy (ADT); however, the effects of different exercise prescriptions are unknown. Objectives: To determine the long-term effects of different exercise modes on fatigue in prostate cancer patients undergoing ADT. Design, setting, and participants: Between 2009 and 2012, 163 prostate cancer patients aged 43-90 y on ADT were randomised to exercise targeting the musculoskeletal system (impact loading + resistance training; ILRT; n = 58), the cardiovascular and muscular systems (aerobic + resistance training; ART; n = 54), or to usual care/delayed exercise (DEL; n = 51) for 12 mo across university-affiliated exercise clinics in Australia. Intervention: Supervised ILRT for 12 mo, supervised ART for 6 mo followed by a 6-mo home program, and DEL received a printed booklet on exercise information for 6 mo followed by 6-mo stationary cycling exercise. Outcome measurements and statistical analysis: Fatigue was assessed using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 36 and vitality using the Short Form-36. Analysis of variance was used to compare outcomes for groups at 6 mo and 12 mo. Results and limitations: Fatigue was reduced (p =0.005) in ILRT at 6 mo and 12 mo (∼5 points), and in ART (p =0.005) and DEL (p =0.022) at 12 mo. Similarly, vitality increased for all groups (p ≤0.001) at 12 mo (∼4 points). Those with the highest levels of fatigue and lowest vitality improved the most with exercise (p trend

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