Effects of dietary nitrate on inflammation and immune function, and implications for cardiovascular health

Kyle Raubenheimer, Catherine Bondonno, Lauren Blekkenhorst, Karl-Heinz Wagner, Jonathan M. Peake, Oliver Neubauer

Research output: Contribution to journalReview article

Abstract

Inorganic dietary nitrate, found abundantly in green leafy and some root vegetables, elicits several beneficial physiological effects, including a reduction in blood pressure and improvements in blood flow through nitrate-nitrite-nitric oxide signaling. Recent animal and human studies have shown that dietary nitrate and nitrite also modulate inflammatory processes and immune cell function and phenotypes. Chronic low-grade inflammation and immune dysfunction play a critical role in cardiovascular disease. This review outlines the current evidence on the efficacy of nitrate-rich plant foods and other sources of dietary nitrate and nitrite to counteract inflammation and promote homeostasis of the immune and vascular systems. The data from these studies suggest that immune cells and immune-vasculature interactions are important targets for dietary interventions aimed at improving, preserving, or restoring cardiovascular health.

Original languageEnglish
Pages (from-to)584-599
Number of pages16
JournalNutrition Reviews
Volume77
Issue number8
DOIs
Publication statusPublished - Aug 2019

Cite this

Raubenheimer, Kyle ; Bondonno, Catherine ; Blekkenhorst, Lauren ; Wagner, Karl-Heinz ; Peake, Jonathan M. ; Neubauer, Oliver. / Effects of dietary nitrate on inflammation and immune function, and implications for cardiovascular health. In: Nutrition Reviews. 2019 ; Vol. 77, No. 8. pp. 584-599.
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abstract = "Inorganic dietary nitrate, found abundantly in green leafy and some root vegetables, elicits several beneficial physiological effects, including a reduction in blood pressure and improvements in blood flow through nitrate-nitrite-nitric oxide signaling. Recent animal and human studies have shown that dietary nitrate and nitrite also modulate inflammatory processes and immune cell function and phenotypes. Chronic low-grade inflammation and immune dysfunction play a critical role in cardiovascular disease. This review outlines the current evidence on the efficacy of nitrate-rich plant foods and other sources of dietary nitrate and nitrite to counteract inflammation and promote homeostasis of the immune and vascular systems. The data from these studies suggest that immune cells and immune-vasculature interactions are important targets for dietary interventions aimed at improving, preserving, or restoring cardiovascular health.",
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Effects of dietary nitrate on inflammation and immune function, and implications for cardiovascular health. / Raubenheimer, Kyle; Bondonno, Catherine; Blekkenhorst, Lauren; Wagner, Karl-Heinz; Peake, Jonathan M.; Neubauer, Oliver.

In: Nutrition Reviews, Vol. 77, No. 8, 08.2019, p. 584-599.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects of dietary nitrate on inflammation and immune function, and implications for cardiovascular health

AU - Raubenheimer, Kyle

AU - Bondonno, Catherine

AU - Blekkenhorst, Lauren

AU - Wagner, Karl-Heinz

AU - Peake, Jonathan M.

AU - Neubauer, Oliver

PY - 2019/8

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N2 - Inorganic dietary nitrate, found abundantly in green leafy and some root vegetables, elicits several beneficial physiological effects, including a reduction in blood pressure and improvements in blood flow through nitrate-nitrite-nitric oxide signaling. Recent animal and human studies have shown that dietary nitrate and nitrite also modulate inflammatory processes and immune cell function and phenotypes. Chronic low-grade inflammation and immune dysfunction play a critical role in cardiovascular disease. This review outlines the current evidence on the efficacy of nitrate-rich plant foods and other sources of dietary nitrate and nitrite to counteract inflammation and promote homeostasis of the immune and vascular systems. The data from these studies suggest that immune cells and immune-vasculature interactions are important targets for dietary interventions aimed at improving, preserving, or restoring cardiovascular health.

AB - Inorganic dietary nitrate, found abundantly in green leafy and some root vegetables, elicits several beneficial physiological effects, including a reduction in blood pressure and improvements in blood flow through nitrate-nitrite-nitric oxide signaling. Recent animal and human studies have shown that dietary nitrate and nitrite also modulate inflammatory processes and immune cell function and phenotypes. Chronic low-grade inflammation and immune dysfunction play a critical role in cardiovascular disease. This review outlines the current evidence on the efficacy of nitrate-rich plant foods and other sources of dietary nitrate and nitrite to counteract inflammation and promote homeostasis of the immune and vascular systems. The data from these studies suggest that immune cells and immune-vasculature interactions are important targets for dietary interventions aimed at improving, preserving, or restoring cardiovascular health.

KW - inorganic nitrate

KW - nitric oxide

KW - vegetables

KW - chronic inflammation

KW - immune-vasculature interactions

KW - IMPROVES VASCULAR FUNCTION

KW - REDUCES BLOOD-PRESSURE

KW - LOW-GRADE INFLAMMATION

KW - NITRIC-OXIDE

KW - INORGANIC NITRATE

KW - OXIDATIVE STRESS

KW - DOUBLE-BLIND

KW - MICROVASCULAR INFLAMMATION

KW - ENDOTHELIAL DYSFUNCTION

KW - SYSTEMIC INFLAMMATION

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JO - Nutrition Reviews

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ER -