EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION: FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE

Fatemeh Baratzadeh; Alexandra E. Butler; Prashant Kesharwani; Seyed Adel Moallem; Amirhossein Sahebkar

doi:10.17179/excli2022-4878

EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION: FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE

Fatemeh Baratzadeh
, Alexandra E. Butler
, Prashant Kesharwani
, Seyed Adel Moallem
, Amirhossein Sahebkar

UWA Medical School

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

Abstract

Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

Original language	English
Pages (from-to)	840-851
Number of pages	12
Journal	EXCLI Journal
Volume	21
DOIs	https://doi.org/10.17179/excli2022-4878
Publication status	Published - 3 Jan 2022

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10.17179/excli2022-4878Licence: CC BY

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title = "EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION: FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE",

abstract = "Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.",

keywords = "anti-ox-LDL, Curcuma longa, Curcumin, ox-LDL, Oxidized low density lipoprotein, Turmeric",

author = "Fatemeh Baratzadeh and Butler, \{Alexandra E.\} and Prashant Kesharwani and Moallem, \{Seyed Adel\} and Amirhossein Sahebkar",

year = "2022",

month = jan,

day = "3",

doi = "10.17179/excli2022-4878",

language = "English",

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pages = "840--851",

journal = "EXCLI Journal",

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publisher = "University of Mainz",

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T1 - EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION

T2 - FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE

AU - Baratzadeh, Fatemeh

AU - Butler, Alexandra E.

AU - Kesharwani, Prashant

AU - Moallem, Seyed Adel

AU - Sahebkar, Amirhossein

PY - 2022/1/3

Y1 - 2022/1/3

N2 - Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

AB - Atherosclerosis is the most frequent cause of death globally. Oxidized low-density lipoprotein (ox-LDL) has an essential role in the formation of atherosclerotic plaques and foamy macrophages. Ox-LDL increases the uptake of cholesterol by macrophages and is the major cause of blood flow disruption. Ox-LDL is produced during oxi-dative stress and treatment with antioxidants could inhibit the production and function of ox-LDL. Curcumin is a potent antioxidant and has a strong track record in the treatment of numerous diseases. Recent studies indicate that Curcumin exerts a lipid-lowering effect, and can modulate the formation of atherosclerotic plaque. The current review focuses upon the role of Curcumin in oxidation of LDL and foam cell formation in atherosclerotic lesions.

KW - anti-ox-LDL

KW - Curcuma longa

KW - Curcumin

KW - ox-LDL

KW - Oxidized low density lipoprotein

KW - Turmeric

UR - https://www.scopus.com/pages/publications/85133249106

U2 - 10.17179/excli2022-4878

DO - 10.17179/excli2022-4878

M3 - Review article

C2 - 36110563

AN - SCOPUS:85133249106

SN - 1611-2156

VL - 21

SP - 840

EP - 851

JO - EXCLI Journal

JF - EXCLI Journal

ER -

EFFECTS OF CURCUMIN ON LOW-DENSITY LIPOPROTEIN OXIDATION: FROM EXPERIMENTAL STUDIES TO CLINICAL PRACTICE

Abstract

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