Effects of curcumin on HDL functionality

Shiva Ganjali, Christopher N. Blesso, Maciej Banach, Matteo Pirro, Muhammed Majeed, Amirhossein Sahebkar

Research output: Contribution to journalReview article

75 Citations (Scopus)

Abstract

Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.

Original languageEnglish
Pages (from-to)208-218
Number of pages11
JournalPharmacological Research
Volume119
DOIs
Publication statusPublished - 1 May 2017

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Curcumin
HDL Cholesterol
Curcuma
Lipid Metabolism
Anti-Inflammatory Agents
Antioxidants
Apolipoprotein A-I
Polyphenols
Hyperlipidemias
Biological Availability
Atherosclerosis
Cardiovascular Diseases
Obesity
Clinical Trials
Therapeutics
Research

Cite this

Ganjali, S., Blesso, C. N., Banach, M., Pirro, M., Majeed, M., & Sahebkar, A. (2017). Effects of curcumin on HDL functionality. Pharmacological Research, 119, 208-218. https://doi.org/10.1016/j.phrs.2017.02.008
Ganjali, Shiva ; Blesso, Christopher N. ; Banach, Maciej ; Pirro, Matteo ; Majeed, Muhammed ; Sahebkar, Amirhossein. / Effects of curcumin on HDL functionality. In: Pharmacological Research. 2017 ; Vol. 119. pp. 208-218.
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Ganjali, S, Blesso, CN, Banach, M, Pirro, M, Majeed, M & Sahebkar, A 2017, 'Effects of curcumin on HDL functionality' Pharmacological Research, vol. 119, pp. 208-218. https://doi.org/10.1016/j.phrs.2017.02.008

Effects of curcumin on HDL functionality. / Ganjali, Shiva; Blesso, Christopher N.; Banach, Maciej; Pirro, Matteo; Majeed, Muhammed; Sahebkar, Amirhossein.

In: Pharmacological Research, Vol. 119, 01.05.2017, p. 208-218.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Effects of curcumin on HDL functionality

AU - Ganjali, Shiva

AU - Blesso, Christopher N.

AU - Banach, Maciej

AU - Pirro, Matteo

AU - Majeed, Muhammed

AU - Sahebkar, Amirhossein

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.

AB - Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subsequently, may alleviate hyperlipidemia and atherosclerosis. Plasma HDL cholesterol (HDL-C) is an independent negative risk predictor of cardiovascular disease (CVD). However, numerous clinical and genetic studies have yielded disappointing results about the therapeutic benefit of raising plasma HDL-C levels. Therefore, research efforts are now focused on improving HDL functionality, independent of HDL-C levels. The quality of HDL particles can vary considerably due to heterogeneity in composition. Consistent with its complexity in composition and metabolism, a wide range of biological activities is reported for HDL, including antioxidant, anti-glycation, anti-inflammatory, anti-thrombotic, anti-apoptotic and immune modulatory activities. Protective properties of curcumin may influence HDL functionality; therefore, we reviewed the literature to determine whether curcumin can augment HDL function. In this review, we concluded that curcumin may modulate markers of HDL function, such as apo-AI, CETP, LCAT, PON1, MPO activities and levels. Curcumin may subsequently improve conditions in which HDL is dysfunctional and may have potential as a therapeutic drug in future. Further clinical trials with bioavailability-improved formulations of curcumin are warranted to examine its effects on lipid metabolism and HDL function.

KW - Atherosclerosis

KW - Cholesterol efflux

KW - Curcumin

KW - Dyslipidemia

KW - High-density lipoprotein

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DO - 10.1016/j.phrs.2017.02.008

M3 - Review article

VL - 119

SP - 208

EP - 218

JO - Pharmacological Research

JF - Pharmacological Research

SN - 1043-6618

ER -

Ganjali S, Blesso CN, Banach M, Pirro M, Majeed M, Sahebkar A. Effects of curcumin on HDL functionality. Pharmacological Research. 2017 May 1;119:208-218. https://doi.org/10.1016/j.phrs.2017.02.008