Abstract
Obstructive sleep apnoea (OSA) is a common and under-recognized breathing disorder associated with excessive sleepiness and impaired cognition. Although these symptoms predispose individuals to increased risk of driving and occupational accidents, the factors that predict increased risk remain unclear because the relationships between OSA and neurobehavioural impairment are complex and vary between individuals. My research broadens knowledge about the association between sleepiness and driving risk in OSA; it reports novel associations between circadian rhythm genes and vulnerability to dozing modulated by severity of OSA; and it validates a simple method to expedite identification of at risk individuals with OSA.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 8 Dec 2016 |
Publication status | Unpublished - 2016 |