Effect of vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana: A secondary analysis from the ObaapaVitA trial | Effet de la supplémentation en vitamine A sur la mortalité relative chez les femmes en âge de procréer au Ghana: Une analyse secondaire de l'étude ObaapaVitA

L.S. Hurt, A.H.A. Ten Asbroek, S. Amenga-Etego, C. Zandoh, S. Danso, Karen Edmond, C.N. Hurt, C.A. Tawiah, Z.E. Hill, J. Fenty, S. Owusu-Agyei, O.M.R. Campbell, B.R. Kirkwood

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Objective To determine the effect of weekly low-dose vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana. Methods A cluster-randomized, triple-blind, placebo-controlled trial was conducted in seven districts of the Brong Ahafo region of Ghana. Women aged 15-45 years who were capable of giving informed consent and intended to live in the trial area for at least 3 months were enrolled and randomly assigned, according to their cluster of residence, to receive oral vitamin A (7500 μg) or placebo once a week. Randomization was blocked, with two clusters in each fieldwork area allocated to vitamin A and two to placebo. Every 4 weeks, fieldworkers distributed capsules and collected data during home visits. Verbal autopsies were conducted by field supervisors and reviewed by physicians, who assigned a cause of death. Cause-specific mortality rates in both arms were compared by means of random-effects Poisson regression models to allow for the cluster randomization. Analysis was by intention-to-treat, based on cluster of residence, with women eligible for inclusion once they had consistently received the supplement or placebo capsules for 6 months. Findings The analysis was based on 581 870 woman-years and 2624 deaths. Cause-specific mortality rates were found to be similar in the two study arms. Conclusion Low-dose vitamin A supplements administered weekly are of no benefit in programmes to reduce mortality in women of childbearing age.
    Original languageEnglish
    Pages (from-to)19-27
    JournalBulletin of the World Health Organization
    Volume91
    Issue number1
    DOIs
    Publication statusPublished - 2013

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