Abstract
Viral infections incur a significant burden on humans and can persist for the lifespan of those infected. Consequently, there is a need to understand host-viral interactions to inform vaccine design. This Thesis focused on two viruses, influenza virus and human immunodeficiency virus, and explored the implications of host-viral interactions on vaccine design. The results of this Thesis provide an in-depth understanding of host-viral interactions, particularly in the context of viral adaptation and its impact on the anti-viral immune response. These findings are important for vaccine design and the ability to develop high efficacy vaccines for several mutable viral pathogens.
Original language | English |
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Qualification | Doctor of Philosophy |
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Award date | 10 Jan 2022 |
DOIs | |
Publication status | Unpublished - 2021 |