Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy

Dick Chan, Jing Pang, P. H R Barrett, D. R. Sullivan, T. A. Mori, J. R. Burnett, F. M. van Bockxmeer, G. F. Watts

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152 Downloads (Pure)

Abstract

Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.

Original languageEnglish
Pages (from-to)1140-1145
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume26
Issue number12
DOIs
Publication statusPublished - 1 Dec 2016

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Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Elasticity
Omega-3 Fatty Acids
Blood Pressure
Fatty Acids
Arteries
Vascular Stiffness
Therapeutics
Triglycerides
Radial Artery
Eicosapentaenoic Acid
Docosahexaenoic Acids
Apolipoproteins B
Cross-Over Studies
Coronary Disease
Pulse
Arterial Pressure
Cardiovascular Diseases
Cholesterol

Cite this

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title = "Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy",
abstract = "Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46{\%} eicosapentaenoic acid and 38{\%} docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9{\%}) and reduced systolic blood pressure (−6{\%}) and diastolic blood pressure (−6{\%}), plasma triglycerides (−20{\%}), apoB concentration (−8{\%}). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.",
keywords = "Atherosclerosis, Cardiovascular disease, Diet and nutrition, Genetics, Hypercholesterolaemia, Vascular dysfunction",
author = "Dick Chan and Jing Pang and Barrett, {P. H R} and Sullivan, {D. R.} and Mori, {T. A.} and Burnett, {J. R.} and {van Bockxmeer}, {F. M.} and Watts, {G. F.}",
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T1 - Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy

AU - Chan, Dick

AU - Pang, Jing

AU - Barrett, P. H R

AU - Sullivan, D. R.

AU - Mori, T. A.

AU - Burnett, J. R.

AU - van Bockxmeer, F. M.

AU - Watts, G. F.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.

AB - Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.

KW - Atherosclerosis

KW - Cardiovascular disease

KW - Diet and nutrition

KW - Genetics

KW - Hypercholesterolaemia

KW - Vascular dysfunction

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