Abstract
Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.
| Original language | English |
|---|---|
| Pages (from-to) | 1140-1145 |
| Number of pages | 6 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 1 Dec 2016 |
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Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy. / Chan, Dick; Pang, Jing; Barrett, P. H R; Sullivan, D. R.; Mori, T. A.; Burnett, J. R.; van Bockxmeer, F. M.; Watts, G. F.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 26, No. 12, 01.12.2016, p. 1140-1145.Research output: Contribution to journal › Article
TY - JOUR
T1 - Effect of omega-3 fatty acid supplementation on arterial elasticity in patients with familial hypercholesterolaemia on statin therapy
AU - Chan, Dick
AU - Pang, Jing
AU - Barrett, P. H R
AU - Sullivan, D. R.
AU - Mori, T. A.
AU - Burnett, J. R.
AU - van Bockxmeer, F. M.
AU - Watts, G. F.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.
AB - Background and aims Increased arterial stiffness is closely linked with raised blood pressure that contributes substantially to enhanced risk of coronary heart disease in high risk individuals with familial hypercholesterolaemia (FH). Omega-3 fatty acid (ω3-FA) supplementation has been demonstrated to lower blood pressure in subjects with a high cardiovascular disease risk. Whether ω3-FA supplementation improves arterial stiffness in FH subjects, on background statin therapy, has yet to be investigated. Method and results We carried out an 8-week randomized, crossover intervention trial to test the effect of 4 g/d ω3-FA supplementation (46% eicosapentaenoic acid and 38% docosahexaenoic acid) on arterial elasticity in 20 adults with FH on optimal cholesterol-lowering therapy. Large and small artery elasticity were measured by pulse contour analysis of the radial artery. ω3-FA supplementation significantly (P < 0.05 in all) increased large artery elasticity (+9%) and reduced systolic blood pressure (−6%) and diastolic blood pressure (−6%), plasma triglycerides (−20%), apoB concentration (−8%). In contrast, ω3-FAs had no significant effect on small artery elasticity. The change in large artery elasticity was not significantly associated with changes in systolic blood pressure or plasma triglyceride concentration. Conclusions ω3-FA supplementation improves large arterial elasticity and arterial blood pressure independent of statin therapy in adults with FH. Clinical Trial Registration: https://www.clinicaltrials.com/ NCT01577056.
KW - Atherosclerosis
KW - Cardiovascular disease
KW - Diet and nutrition
KW - Genetics
KW - Hypercholesterolaemia
KW - Vascular dysfunction
UR - http://www.scopus.com/inward/record.url?scp=84995467664&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2016.07.012
DO - 10.1016/j.numecd.2016.07.012
M3 - Article
VL - 26
SP - 1140
EP - 1145
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 12
ER -