Effect of omega-3 fatty acid supplementation during pregnancy or infancy on cardio-metabolic risk factors in childhood

Valene Hsu Lin See

doi:10.4225/23/5934fe710cf03

Effect of omega-3 fatty acid supplementation during pregnancy or infancy on cardio-metabolic risk factors in childhood

Valene Hsu Lin See

Research output: Thesis › Doctoral Thesis

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Abstract

A global epidemic of childhood obesity is projected to increase adult cardiovascular risk within the next generation. Animal studies suggest omega-3 fatty acids in pregnancy and infancy protect against cardiovascular risk in the offspring. However, few studies have examined whether this is true In humans. We hypothesised that supplementation during pregnancy or infancy would program improvements in blood pressure, blood lipids, mediators of inflammation and oxidative stress, and DNA telomeres. We showed omega-3 fatty acids were beneficial in the offspring Immediately following supplementation but there were no long-term benefits. These data provide a platform for future large-scale randomised controlled trials.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Huang, Rae-Chi, Supervisor Prescott, Susan, Supervisor Mori, Trevor, Supervisor
Award date	9 May 2017
DOIs	https://doi.org/10.4225/23/5934fe710cf03
Publication status	Unpublished - 2017

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10.4225/23/5934fe710cf03

THESIS - DOCTOR OF PHILOSOPHY - SEE Valene Hsu Lin - 2017
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Cite this

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abstract = "A global epidemic of childhood obesity is projected to increase adult cardiovascular risk within the next generation. Animal studies suggest omega-3 fatty acids in pregnancy and infancy protect against cardiovascular risk in the offspring. However, few studies have examined whether this is true In humans. We hypothesised that supplementation during pregnancy or infancy would program improvements in blood pressure, blood lipids, mediators of inflammation and oxidative stress, and DNA telomeres. We showed omega-3 fatty acids were beneficial in the offspring Immediately following supplementation but there were no long-term benefits. These data provide a platform for future large-scale randomised controlled trials.",

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AB - A global epidemic of childhood obesity is projected to increase adult cardiovascular risk within the next generation. Animal studies suggest omega-3 fatty acids in pregnancy and infancy protect against cardiovascular risk in the offspring. However, few studies have examined whether this is true In humans. We hypothesised that supplementation during pregnancy or infancy would program improvements in blood pressure, blood lipids, mediators of inflammation and oxidative stress, and DNA telomeres. We showed omega-3 fatty acids were beneficial in the offspring Immediately following supplementation but there were no long-term benefits. These data provide a platform for future large-scale randomised controlled trials.

KW - Omega-3 fatty acids

KW - Pregnancy

KW - Infancy

KW - Programming

KW - Cardio-metabolic risk factors

KW - Specialized pro-resolving mediators

KW - Oxidative stress

KW - Telomere length

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DO - 10.4225/23/5934fe710cf03

M3 - Doctoral Thesis

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Effect of omega-3 fatty acid supplementation during pregnancy or infancy on cardio-metabolic risk factors in childhood

Abstract

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