Effect of omega-3 fatty acid ethyl esters on postprandial arterial elasticity in patients with familial hypercholesterolemia

Qidi Ying, Dick C Chan, Jing Pang, Mikaël Croyal, Valentin Blanchard, Michel Krempf, Gerald F Watts

Research output: Contribution to journalArticlepeer-review

Abstract

Background
Impaired arterial elasticity reflects increased risk of atherosclerotic cardiovascular disease in patients with familial hypercholesterolemia (FH). Treatment with omega-3 fatty acid ethyl esters (ω-3FAEEs) in FH patients has been shown to improve postprandial triglyceride-rich lipoprotein (TRL) metabolism, including TRL-apolipoprotein(a) [TRL-apo(a)]. Whether ω-3FAEE intervention also improves postprandial arterial elasticity in FH has not been demonstrated.

Methods
We carried out an 8-week open-label, randomized, crossover trial to test the effect of ω-3FAEEs (4 g/day) on postprandial arterial elasticity in 20 FH subjects following ingestion of an oral fat load. Fasting and postprandial large (C1) and small (C2) artery elasticity at 4 h and 6 h were measured by pulse contour analysis of the radial artery. The area under-the-curves (AUCs) (0-6hr) for C1, C2, plasma triglycerides and TRL-apo(a) were determined using the trapezium rule.

Results
Compared with no treatment, ω-3FAEEs significantly increased fasting (+9%, P
Conclusions
High-dose ω-3FAEEs improves postprandial large artery elasticity in adults with FH. Reduction in postprandial TRL-apo(a) with ω-3FAEEs may contribute to the improvement in large artery elasticity. However, our findings need to be confirmed in a larger population.
Original languageEnglish
Pages (from-to)174-177
Number of pages4
JournalClinical Nutrition ESPEN
Volume55
DOIs
Publication statusPublished - Jun 2023

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