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Drug-induced spoliation of hydrogels as contact lenses or as implants in the anterior eye is a frequent occurrence in clinical practice. Thisstudy explores the capacity of three commercial multipurpose solutions for contact lens care to reduce the spoliation of poly(2-hydroxyethylmethacrylate) (PHEMA) specimens exposed to a simulated aqueous humour formulation and to three topical drugs commonly administeredafter insertion of artificial corneas (Predsol, Optimol and Depo-Ralovera). ReNu MultiPlus1 (Bausch & Lomb), Complete1 Blink-NCleanTM Lens Drops (Allergan) and Complete Protein Remover Tablets dissolved in Complete1 ComfortPLUSTM (both from Allergan) wereevaluated. All multipurpose solutions were able to dislodge passively the deposits formed on hydrogels in the simulated aqueous and in thepresence of Predsol and Optimol, but none were effective against the deposits induced by Depo-Ralovera. A reduction of the calcium contentin deposits caused by Predsol and Optimol was confirmed after treatment with the protein remover preparation, while the other multipurposesolutions caused the complete removal of the deposits. In experiments designed to evaluate the preventive action of the multipurposesolutions, no such effects were observed regardless of the drug involved. The prospect of using multipurpose solutions as eye drops followingimplantation of a hydrogel artificial cornea is a valid alternative for reducing device spoliation, however it appears to depend on the nature ofthe postoperative medication. ©2004 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.