Effect of magnetic fields on a rodent model of transient focal cerebral ischaemia

Vince Clark

    Research output: ThesisMaster's Thesis

    152 Downloads (Pure)

    Abstract

    Brain ischaemia, or stroke, is a debilitating condition where neural tissue is deprived of oxygen and nutrients which can result in functional or cognitive deficits and possibly death. Stroke survivors often suffer a long and arduous recovery involving physiotherapy which can be painful and frustrating with little certainty of a full recovery. New stroke therapies are attempting to establish methods to facilitate functional recovery by developing non-invasive protocols to increase compliance and improve functional outcomes. The application of pulsed magnetic fields (PMFs) is a non-invasive technique using magnetic fields applied transcranially in an attempt to stimulate underlying neural tissue into reorganising and repairing non-functioning neuronal circuits. This project applied PMFs to a rat model of stroke for 28 days and aimed to quantify treatment effects at both the functional and neural tissue level. 20Hz PMF was administered to rats immediately after stroke for 2 days followed by either 1Hz or 6-9Hz PMF's administered each day for a further 26 days (n=3 per group). Functional testing (5-point scale of deficit, Garcia neurological score, bilateral paw asymmetry and open field) was performed pre-surgically and at days 2, 8 and 28. Electroencephalograph metrics were recorded on day 28. Following the recording session brain infarct volume was determined and analysed to determine if the electroencephalograph metrics correlated with brain injury. PMF treatment at the frequencies and intensities used did not facilitate functional improvement, nor was there any evidence that the treatment worsened outcomes. It is possible that the small group sample size was not powered to detect small functional improvements provided by PMF treatment.
    Original languageEnglish
    QualificationMasters
    Publication statusUnpublished - 2012

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