Effect of intramuscular and blood buffering agents on exercise performance

Kagan Ducker

    Research output: ThesisDoctoral Thesis

    255 Downloads (Pure)


    Beta‐alanine (beta‐amino acid) supplementation may improve the hydrogen ion buffering capacity of the body. When beta‐alanine is ingested, it combines with histidine within the myocytes and carnosine is formed. Carnosine is a significant H+ buffer within the muscles (pKa = 6.83), with high intramuscular concentrations being linked with improved high‐intensity exercise performance. Serially loading with a dose of 3 – 6 g-day‐1 of beta‐alanine for at least 4 weeks may have little to no side effects, yet may improve performance during high‐intensity sustained‐sprint exercise (2 – 4 min) and weight training (i.e. increased volume). Literature related to beta‐alanine supplementation is currently limited regarding ergogenic effects (if any) in exercise performances that closely mimic the physiological requirements of sporting match play and races. Further, little is known about whether the combination of sodium bicarbonate (extracellular blood buffer) and beta‐alanine (intracellular muscle buffer via carnosine) supplementation can lead to enhanced exercise performance beyond what is possible with either supplement alone.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Publication statusUnpublished - 2013


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