TY - JOUR
T1 - Effect of early kangaroo mother care on time to full feeds in preterm infants - A prospective cohort study
AU - Pandya, Dhyey
AU - Kartikeswar, Gouda Ankula Prasad
AU - Patwardhan, Gaurav
AU - Kadam, Sandeep
AU - Pandit, Anand
AU - Patole, Sanjay
PY - 2021/3
Y1 - 2021/3
N2 - Background: Kangaroo mother care (KMC) is known to reduce neonatal mortality and morbidity. In preterm neonates, KMC is usually initiated only after stabilization. Aims: We aimed to assess if early initiation of KMC starting within the first week of life is safe, and reduces the time to full feeds (TFF) in preterm neonates. Study design: Prospective cohort study. Subjects: Preterm neonates (Gestation ≤ 34 weeks, Birth weight ≤ 1250 g). This was studied in two epochs, (epoch 1) which was before early KMC vs. epoch 2 which was after implementation of early KMC even if they needed respiratory support, with umbilical/central lines in situ. Outcome: The primary outcome of the study was time to establish full feeds (TFF) of 150 ml/kg/day. Results: The neonatal demographic characteristics were comparable between epoch 1 and epoch 2 except for lower gestational age, higher surfactant, and any respiratory support in epoch 2. On univariate analysis, early KMC significantly reduced TFF (12.5 vs. 9 days, P < 0.001). Feed intolerance, duration of parenteral nutrition were significantly reduced, and discharge weight Z score improved significantly in epoch 2. On multivariate regression analysis early KMC, exclusive mother's own milk feeding and blood culture-positive late-onset sepsis were important predictors of TFF. Early KMC was safe and well-tolerated. Conclusion: Early KMC was safe and associated with reduced TFF and other nutritional benefits in moderately ill preterm neonates.
AB - Background: Kangaroo mother care (KMC) is known to reduce neonatal mortality and morbidity. In preterm neonates, KMC is usually initiated only after stabilization. Aims: We aimed to assess if early initiation of KMC starting within the first week of life is safe, and reduces the time to full feeds (TFF) in preterm neonates. Study design: Prospective cohort study. Subjects: Preterm neonates (Gestation ≤ 34 weeks, Birth weight ≤ 1250 g). This was studied in two epochs, (epoch 1) which was before early KMC vs. epoch 2 which was after implementation of early KMC even if they needed respiratory support, with umbilical/central lines in situ. Outcome: The primary outcome of the study was time to establish full feeds (TFF) of 150 ml/kg/day. Results: The neonatal demographic characteristics were comparable between epoch 1 and epoch 2 except for lower gestational age, higher surfactant, and any respiratory support in epoch 2. On univariate analysis, early KMC significantly reduced TFF (12.5 vs. 9 days, P < 0.001). Feed intolerance, duration of parenteral nutrition were significantly reduced, and discharge weight Z score improved significantly in epoch 2. On multivariate regression analysis early KMC, exclusive mother's own milk feeding and blood culture-positive late-onset sepsis were important predictors of TFF. Early KMC was safe and well-tolerated. Conclusion: Early KMC was safe and associated with reduced TFF and other nutritional benefits in moderately ill preterm neonates.
KW - Early KMC
KW - mother's own milk
KW - Neonate
KW - Skin to skin contact
KW - Time to full feeds
UR - http://www.scopus.com/inward/record.url?scp=85099849524&partnerID=8YFLogxK
U2 - 10.1016/j.earlhumdev.2021.105312
DO - 10.1016/j.earlhumdev.2021.105312
M3 - Article
C2 - 33517173
AN - SCOPUS:85099849524
VL - 154
JO - Early Human Development
JF - Early Human Development
SN - 0378-3782
M1 - 105312
ER -