Effect of dietary Fatty acids on human lipoprotein metabolism: A comprehensive update

    Research output: Contribution to journalReview article

    39 Citations (Scopus)

    Abstract

    Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic triglyceride-rich lipoprotein (TRL) secretion and enhanced TRL to low-density lipoprotein (LDL) conversion. n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion. High n-6 PUFA intake decreased very low-density lipoprotein (VLDL) cholesterol and triglyceride concentrations by up-regulating VLDL lipolysis and uptake. In a study of healthy subjects, the intake of saturated fatty-acids with increased palmitic acid at the sn-2 position was associated with decreased postprandial lipemia. Low medium-chain triglyceride may not appreciably alter TRL metabolism. Replacing carbohydrate with monounsaturated fatty-acids increased TRL catabolism. Trans-fatty-acid decreased LDL and enhanced high-density lipoprotein catabolism. Interactions between APOE genotype and n-3 PUFA in regulating lipid responses were also described. The major advances in understanding the effect of dietary fatty-acids on lipoprotein metabolism has centered on n-3 PUFA. This knowledge emphasizes the importance of regulating lipoprotein metabolism as a mode to improve plasma lipids and potentially CVD risk. Additional studies are required to better characterize the cardiometabolic effects of other dietary fatty-acids.

    Original languageEnglish
    Pages (from-to)4416-4425
    Number of pages10
    JournalNutrients
    Volume7
    Issue number6
    DOIs
    Publication statusPublished - 2 Jun 2015

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    dietary fat
    lipoproteins
    Lipoproteins
    Fatty Acids
    metabolism
    Triglycerides
    triacylglycerols
    Omega-3 Fatty Acids
    polyunsaturated fatty acids
    omega-3 fatty acids
    hyperlipidemia
    Apolipoprotein B-48
    cardiovascular diseases
    Cardiovascular Diseases
    very low density lipoprotein
    low density lipoprotein
    Hyperlipidemias
    LDL Lipoproteins
    secretion
    Trans Fatty Acids

    Cite this

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    title = "Effect of dietary Fatty acids on human lipoprotein metabolism: A comprehensive update",
    abstract = "Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic triglyceride-rich lipoprotein (TRL) secretion and enhanced TRL to low-density lipoprotein (LDL) conversion. n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion. High n-6 PUFA intake decreased very low-density lipoprotein (VLDL) cholesterol and triglyceride concentrations by up-regulating VLDL lipolysis and uptake. In a study of healthy subjects, the intake of saturated fatty-acids with increased palmitic acid at the sn-2 position was associated with decreased postprandial lipemia. Low medium-chain triglyceride may not appreciably alter TRL metabolism. Replacing carbohydrate with monounsaturated fatty-acids increased TRL catabolism. Trans-fatty-acid decreased LDL and enhanced high-density lipoprotein catabolism. Interactions between APOE genotype and n-3 PUFA in regulating lipid responses were also described. The major advances in understanding the effect of dietary fatty-acids on lipoprotein metabolism has centered on n-3 PUFA. This knowledge emphasizes the importance of regulating lipoprotein metabolism as a mode to improve plasma lipids and potentially CVD risk. Additional studies are required to better characterize the cardiometabolic effects of other dietary fatty-acids.",
    keywords = "Apolipoproteins E, Cardiovascular Diseases, Cholesterol, HDL, Cholesterol, VLDL, Dyslipidemias, Fatty Acids, Fatty Acids, Monounsaturated, Fatty Acids, Omega-3, Fatty Acids, Omega-6, Humans, Lipid Metabolism, Randomized Controlled Trials as Topic, Risk Factors, Triglycerides, Journal Article, Research Support, Non-U.S. Gov't, Review",
    author = "Ooi, {Esther M M} and Watts, {Gerald F} and Ng, {Theodore W K} and Barrett, {P Hugh R}",
    year = "2015",
    month = "6",
    day = "2",
    doi = "10.3390/nu7064416",
    language = "English",
    volume = "7",
    pages = "4416--4425",
    journal = "Nutrients",
    issn = "2072-6643",
    publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
    number = "6",

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    Effect of dietary Fatty acids on human lipoprotein metabolism : A comprehensive update. / Ooi, Esther M M; Watts, Gerald F; Ng, Theodore W K; Barrett, P Hugh R.

    In: Nutrients, Vol. 7, No. 6, 02.06.2015, p. 4416-4425.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Effect of dietary Fatty acids on human lipoprotein metabolism

    T2 - A comprehensive update

    AU - Ooi, Esther M M

    AU - Watts, Gerald F

    AU - Ng, Theodore W K

    AU - Barrett, P Hugh R

    PY - 2015/6/2

    Y1 - 2015/6/2

    N2 - Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic triglyceride-rich lipoprotein (TRL) secretion and enhanced TRL to low-density lipoprotein (LDL) conversion. n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion. High n-6 PUFA intake decreased very low-density lipoprotein (VLDL) cholesterol and triglyceride concentrations by up-regulating VLDL lipolysis and uptake. In a study of healthy subjects, the intake of saturated fatty-acids with increased palmitic acid at the sn-2 position was associated with decreased postprandial lipemia. Low medium-chain triglyceride may not appreciably alter TRL metabolism. Replacing carbohydrate with monounsaturated fatty-acids increased TRL catabolism. Trans-fatty-acid decreased LDL and enhanced high-density lipoprotein catabolism. Interactions between APOE genotype and n-3 PUFA in regulating lipid responses were also described. The major advances in understanding the effect of dietary fatty-acids on lipoprotein metabolism has centered on n-3 PUFA. This knowledge emphasizes the importance of regulating lipoprotein metabolism as a mode to improve plasma lipids and potentially CVD risk. Additional studies are required to better characterize the cardiometabolic effects of other dietary fatty-acids.

    AB - Dyslipidemia is a major risk factor for cardiovascular disease (CVD). Dietary fatty-acid composition regulates lipids and lipoprotein metabolism and may confer CVD benefit. This review updates understanding of the effect of dietary fatty-acids on human lipoprotein metabolism. In elderly participants with hyperlipidemia, high n-3 polyunsaturated fatty-acids (PUFA) consumption diminished hepatic triglyceride-rich lipoprotein (TRL) secretion and enhanced TRL to low-density lipoprotein (LDL) conversion. n-3 PUFA also decreased TRL-apoB-48 concentration by decreasing TRL-apoB-48 secretion. High n-6 PUFA intake decreased very low-density lipoprotein (VLDL) cholesterol and triglyceride concentrations by up-regulating VLDL lipolysis and uptake. In a study of healthy subjects, the intake of saturated fatty-acids with increased palmitic acid at the sn-2 position was associated with decreased postprandial lipemia. Low medium-chain triglyceride may not appreciably alter TRL metabolism. Replacing carbohydrate with monounsaturated fatty-acids increased TRL catabolism. Trans-fatty-acid decreased LDL and enhanced high-density lipoprotein catabolism. Interactions between APOE genotype and n-3 PUFA in regulating lipid responses were also described. The major advances in understanding the effect of dietary fatty-acids on lipoprotein metabolism has centered on n-3 PUFA. This knowledge emphasizes the importance of regulating lipoprotein metabolism as a mode to improve plasma lipids and potentially CVD risk. Additional studies are required to better characterize the cardiometabolic effects of other dietary fatty-acids.

    KW - Apolipoproteins E

    KW - Cardiovascular Diseases

    KW - Cholesterol, HDL

    KW - Cholesterol, VLDL

    KW - Dyslipidemias

    KW - Fatty Acids

    KW - Fatty Acids, Monounsaturated

    KW - Fatty Acids, Omega-3

    KW - Fatty Acids, Omega-6

    KW - Humans

    KW - Lipid Metabolism

    KW - Randomized Controlled Trials as Topic

    KW - Risk Factors

    KW - Triglycerides

    KW - Journal Article

    KW - Research Support, Non-U.S. Gov't

    KW - Review

    U2 - 10.3390/nu7064416

    DO - 10.3390/nu7064416

    M3 - Review article

    VL - 7

    SP - 4416

    EP - 4425

    JO - Nutrients

    JF - Nutrients

    SN - 2072-6643

    IS - 6

    ER -