Effect of combination therapy on arterial function in statin-treated type 2 diabetic patients

Sandy Hamilton

Effect of combination therapy on arterial function in statin-treated type 2 diabetic patients

Sandy Hamilton

Research output: Thesis › Doctoral Thesis

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Abstract

[Truncated abstract] Type 2 diabetes mellitus (T2DM) markedly increases the risk of all forms of cardiovascular disease (CVD). Arterial dysfunction is an early feature and predictor of diabetic vascular disease and is causally related to diabetic dyslipidaemia. Statins, recommended as first-line therapy for diabetic dyslipidaemia, decrease CVD events principally by reducing LDL particle concentrations. However, their vascular benefits may be attenuated by inhibition of coenzyme Q10 (CoQ10) production. Therapeutic guidelines recommend LDL-cholesterol be lowered to a target goal of

Original language	English
Qualification	Doctor of Philosophy
Publication status	Unpublished - 2011

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title = "Effect of combination therapy on arterial function in statin-treated type 2 diabetic patients",

abstract = "[Truncated abstract] Type 2 diabetes mellitus (T2DM) markedly increases the risk of all forms of cardiovascular disease (CVD). Arterial dysfunction is an early feature and predictor of diabetic vascular disease and is causally related to diabetic dyslipidaemia. Statins, recommended as first-line therapy for diabetic dyslipidaemia, decrease CVD events principally by reducing LDL particle concentrations. However, their vascular benefits may be attenuated by inhibition of coenzyme Q10 (CoQ10) production. Therapeutic guidelines recommend LDL-cholesterol be lowered to a target goal of",

keywords = "Statins, Niacin, Combination therapy, Type 2 diabetes, Arterial function, Coenzyme Q10, Fenofibrate, Hypertriglyceridemia",

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T1 - Effect of combination therapy on arterial function in statin-treated type 2 diabetic patients

AU - Hamilton, Sandy

PY - 2011

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N2 - [Truncated abstract] Type 2 diabetes mellitus (T2DM) markedly increases the risk of all forms of cardiovascular disease (CVD). Arterial dysfunction is an early feature and predictor of diabetic vascular disease and is causally related to diabetic dyslipidaemia. Statins, recommended as first-line therapy for diabetic dyslipidaemia, decrease CVD events principally by reducing LDL particle concentrations. However, their vascular benefits may be attenuated by inhibition of coenzyme Q10 (CoQ10) production. Therapeutic guidelines recommend LDL-cholesterol be lowered to a target goal of

AB - [Truncated abstract] Type 2 diabetes mellitus (T2DM) markedly increases the risk of all forms of cardiovascular disease (CVD). Arterial dysfunction is an early feature and predictor of diabetic vascular disease and is causally related to diabetic dyslipidaemia. Statins, recommended as first-line therapy for diabetic dyslipidaemia, decrease CVD events principally by reducing LDL particle concentrations. However, their vascular benefits may be attenuated by inhibition of coenzyme Q10 (CoQ10) production. Therapeutic guidelines recommend LDL-cholesterol be lowered to a target goal of

KW - Statins

KW - Niacin

KW - Combination therapy

KW - Type 2 diabetes

KW - Arterial function

KW - Coenzyme Q10

KW - Fenofibrate

KW - Hypertriglyceridemia

M3 - Doctoral Thesis

ER -

Effect of combination therapy on arterial function in statin-treated type 2 diabetic patients

Abstract

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