Abstract
Birthweight has a well-established role on long-term cardiovascular outcomes. Cardiac magnetic resonance (CMR) with feature tracking strain analysis is the gold standard for assessing cardiac structure and function, and can detect subclinical dysfunction. This study investigated, using CMR, the long-term effects of birthweight on cardiac structure and function in young adults.
This study assessed cardiac structure and function in the offspring of women enrolled during pregnancy in the Raine Study. Participants all underwent a CMR at 27 years; image segmentation and strain analysis were undertaken by blinded investigators. Participants were stratified into three birthweight categories for analysis: low birthweight (LBW <2,500 g), normal birthweight (NBW 2500–4000 g), and high birthweight (HBW ≥4000 g).
A total of 496 participants were included in the final analysis: 40 in the LBW, 405 in the NBW, and 51 in the HBW group. Left ventricular mass index was significantly increased in the HBW compared with others (44.4 g/m2 vs 48.3 g/m2 vs 50.0 g/m2 for LBW, NBW, and HBW, respectively; p=0.005). Right ventricular stroke volume index, end systolic volume index, and end diastolic volume index also demonstrated significant increases from LBW to HBW (p=0.02; p=0.01; p<0.001, respectively). Left ventricular global longitudinal, radial and circumferential strain showed worsening function with HBW compared with LBW (p=0.02; p=0.03; p=0.045, respectively). Right ventricular global circumferential strain was significantly reduced in the HBW group compared with NBW (–8.6% vs –10.1%; p=0.0013).
A higher birth weight is associated with subclinical structural and functional cardiac changes in young adulthood that may influence long-term cardiac outcomes.
This study assessed cardiac structure and function in the offspring of women enrolled during pregnancy in the Raine Study. Participants all underwent a CMR at 27 years; image segmentation and strain analysis were undertaken by blinded investigators. Participants were stratified into three birthweight categories for analysis: low birthweight (LBW <2,500 g), normal birthweight (NBW 2500–4000 g), and high birthweight (HBW ≥4000 g).
A total of 496 participants were included in the final analysis: 40 in the LBW, 405 in the NBW, and 51 in the HBW group. Left ventricular mass index was significantly increased in the HBW compared with others (44.4 g/m2 vs 48.3 g/m2 vs 50.0 g/m2 for LBW, NBW, and HBW, respectively; p=0.005). Right ventricular stroke volume index, end systolic volume index, and end diastolic volume index also demonstrated significant increases from LBW to HBW (p=0.02; p=0.01; p<0.001, respectively). Left ventricular global longitudinal, radial and circumferential strain showed worsening function with HBW compared with LBW (p=0.02; p=0.03; p=0.045, respectively). Right ventricular global circumferential strain was significantly reduced in the HBW group compared with NBW (–8.6% vs –10.1%; p=0.0013).
A higher birth weight is associated with subclinical structural and functional cardiac changes in young adulthood that may influence long-term cardiac outcomes.
Original language | English |
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Pages (from-to) | S238-S239 |
Journal | Heart, Lung and Circulation |
Volume | 32 |
DOIs | |
Publication status | Published - Jul 2023 |
Event | Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand - Adelaide, Australia Duration: 3 Aug 2023 → 6 Aug 2023 Conference number: 71 |