Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer's Disease: A preliminary Study

Y.Y. Lim, V.L. Villemagne, S.M. Laws, D. Ames, R.H. Pietrzak, K.A. Ellis, K. Harrington, P. Bourgeat, A.I. Bush, Ralph Martins, C.L. Masters, C.C. Rowe, P. Maruff

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Objective
    Cross-sectional genetic association studies have reported equivocal results on the relationship between the brain-derived neurotrophic factor (BDNF) Val66Met and risk of Alzheimer’s disease (AD). As AD is a neurodegenerative disease, genetic influences may become clearer from prospective study. We aimed to determine whether BDNF Val66Met polymorphism influences changes in memory performance, hippocampal volume, and Aβ accumulation in adults with amnestic mild cognitive impairment (aMCI) and high Aβ.

    Methods
    Thirty-four adults with aMCI were recruited from the Australian, Imaging, Biomarkers and Lifestyle (AIBL) Study. Participants underwent PiB-PET and structural MRI neuroimaging, neuropsychological assessments and BDNF genotyping at baseline, 18 month, and 36 month assessments.

    Results
    In individuals with aMCI and high Aβ, Met carriers showed significant and large decline in episodic memory (d = 0.90, p = .020) and hippocampal volume (d = 0.98, p = .035). BDNF Val66Met was unrelated to the rate of Aβ accumulation (d = −0.35, p = .401).

    Conclusions
    Although preliminary due to the small sample size, results of this study suggest that high Aβ levels and Met carriage may be useful prognostic markers of accelerated decline in episodic memory, and reductions in hippocampal volume in individuals in the prodromal or MCI stage of AD.

    Original languageEnglish
    Pages (from-to)e86498
    JournalPLoS One
    Volume9
    Issue number1
    DOIs
    Publication statusPublished - 27 Jan 2014

      Fingerprint

    Cite this

    Lim, Y. Y., Villemagne, V. L., Laws, S. M., Ames, D., Pietrzak, R. H., Ellis, K. A., ... Maruff, P. (2014). Effect of BDNF Val66Met on Memory Decline and Hippocampal Atrophy in Prodromal Alzheimer's Disease: A preliminary Study. PLoS One, 9(1 ), e86498. https://doi.org/10.1371/journal.pone.0086498