Effect of a short sprint on glucose production and whole body glucose utilisation in adults with Type 1 diabetes

Avril Joy Fahey

    Research output: ThesisMaster's Thesis

    200 Downloads (Pure)

    Abstract

    Exercise in individuals with type 1 diabetes mellitus (T1DM) can increase the risk of hypoglycaemia. Recently, however, we showed that a 10-second maximal sprint effort performed after moderate intensity exercise in those individuals can prevent blood glucose levels from falling (Bussau VA, Ferreira LD, Jones TW, Fournier PA. 2006. The 10-s maximal sprint-A novel approach to counter an exercise-mediated fall in glycemia in individuals with type 1 diabetes. Diabetes Care, 29, 601-601). We hypothesised that this protective effect of sprinting results from a more pronounced post-sprinting rise in the rate of glucose appearance (Ra) compared to the rate of peripheral glucose disappearance (Rd). To test whether sprinting per se has such an effect on glucose Ra and Rd, eight T1DM participants completed a 10-second maximal sprint during an euinsulinaemic euglycaemic clamp and were compared to non-diabetic individuals. Immediately after the 10 second sprint, blood glucose levels increased by 1.04±0.58 mM (p=0.001) in the diabetic participants and rose transiently by in the non-diabetic group. During the 2 hour recovery, Ra in both groups did not change significantly (p>0.05). In contrast, Rd fell significantly by 1.33 mg/ml-1.kg-1 and 57% relative to Ra and pre-exercise Rd levels, respectively, before returning within 30 minutes to pre-exercise levels in the diabetic participants, and fell by 38% relative to Ra in the non-diabetic group. In response to sprinting, the levels of epinephrine and norepinephrine in the diabetic group rose by 8 and 4 fold, respectively, and 9.5 and 6 fold in the non-diabetic participants (p
    Original languageEnglish
    QualificationMasters
    Publication statusUnpublished - 2010

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