Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol

Australian JDRF Closed-Loop Res Gr

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction Automated insulin delivery (also known as closed loop, or artificial pancreas) has shown potential to improve glycaemic control and quality of life in people with type 1 diabetes (T1D). Automated insulin delivery devices incorporate an insulin pump with continuous glucose monitoring(CGM) and an algorithm, and adjust insulin in real time. This study aims to establish the safety and efficacy of a hybrid closed-loop (HCL) system in a long-term outpatient trial in people with T1D aged 12 -

Methods and analysis This is an open-label, multicentre, 6-month, randomised controlled home trial to test the MiniMed Medtronic 670G system (HCL) in people with T1D aged 12 -

Ethics and dissemination Ethics committee permissions were gained from respective institutional review boards. The findings of the study will provide high-quality evidence on the role of HCL in clinical practice.

Original languageEnglish
Article number020275
Number of pages8
JournalBMJ Open
Volume8
Issue number8
DOIs
Publication statusPublished - Aug 2018

Cite this

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title = "Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes: a randomised controlled trial protocol",
abstract = "Introduction Automated insulin delivery (also known as closed loop, or artificial pancreas) has shown potential to improve glycaemic control and quality of life in people with type 1 diabetes (T1D). Automated insulin delivery devices incorporate an insulin pump with continuous glucose monitoring(CGM) and an algorithm, and adjust insulin in real time. This study aims to establish the safety and efficacy of a hybrid closed-loop (HCL) system in a long-term outpatient trial in people with T1D aged 12 -Methods and analysis This is an open-label, multicentre, 6-month, randomised controlled home trial to test the MiniMed Medtronic 670G system (HCL) in people with T1D aged 12 -Ethics and dissemination Ethics committee permissions were gained from respective institutional review boards. The findings of the study will provide high-quality evidence on the role of HCL in clinical practice.",
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author = "{Australian JDRF Closed-Loop Res Gr} and {de Bock}, Martin and McAuley, {Sybil A.} and Abraham, {Mary Binsu} and Grant Smith and Jennifer Nicholas and Ambler, {Geoff R.} and Cameron, {Fergus J.} and Fairchild, {Jan M.} and King, {Bruce R.} and Geelhoed, {Elizabeth A.} and Davis, {Elizabeth A.} and O'Neal, {David Norman} and Jones, {Timothy W.}",
year = "2018",
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doi = "10.1136/bmjopen-2017-020275",
language = "English",
volume = "8",
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Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes : a randomised controlled trial protocol. / Australian JDRF Closed-Loop Res Gr.

In: BMJ Open, Vol. 8, No. 8, 020275, 08.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of 6 months hybrid closed-loop insulin delivery in young people with type 1 diabetes

T2 - a randomised controlled trial protocol

AU - Australian JDRF Closed-Loop Res Gr

AU - de Bock, Martin

AU - McAuley, Sybil A.

AU - Abraham, Mary Binsu

AU - Smith, Grant

AU - Nicholas, Jennifer

AU - Ambler, Geoff R.

AU - Cameron, Fergus J.

AU - Fairchild, Jan M.

AU - King, Bruce R.

AU - Geelhoed, Elizabeth A.

AU - Davis, Elizabeth A.

AU - O'Neal, David Norman

AU - Jones, Timothy W.

PY - 2018/8

Y1 - 2018/8

N2 - Introduction Automated insulin delivery (also known as closed loop, or artificial pancreas) has shown potential to improve glycaemic control and quality of life in people with type 1 diabetes (T1D). Automated insulin delivery devices incorporate an insulin pump with continuous glucose monitoring(CGM) and an algorithm, and adjust insulin in real time. This study aims to establish the safety and efficacy of a hybrid closed-loop (HCL) system in a long-term outpatient trial in people with T1D aged 12 -Methods and analysis This is an open-label, multicentre, 6-month, randomised controlled home trial to test the MiniMed Medtronic 670G system (HCL) in people with T1D aged 12 -Ethics and dissemination Ethics committee permissions were gained from respective institutional review boards. The findings of the study will provide high-quality evidence on the role of HCL in clinical practice.

AB - Introduction Automated insulin delivery (also known as closed loop, or artificial pancreas) has shown potential to improve glycaemic control and quality of life in people with type 1 diabetes (T1D). Automated insulin delivery devices incorporate an insulin pump with continuous glucose monitoring(CGM) and an algorithm, and adjust insulin in real time. This study aims to establish the safety and efficacy of a hybrid closed-loop (HCL) system in a long-term outpatient trial in people with T1D aged 12 -Methods and analysis This is an open-label, multicentre, 6-month, randomised controlled home trial to test the MiniMed Medtronic 670G system (HCL) in people with T1D aged 12 -Ethics and dissemination Ethics committee permissions were gained from respective institutional review boards. The findings of the study will provide high-quality evidence on the role of HCL in clinical practice.

KW - clinical trials

KW - paediatrics

KW - SYSTEM

KW - ONSET

U2 - 10.1136/bmjopen-2017-020275

DO - 10.1136/bmjopen-2017-020275

M3 - Article

VL - 8

JO - BMJ (Open)

JF - BMJ (Open)

SN - 2044-6055

IS - 8

M1 - 020275

ER -