Ectrodactyly in a Chinese patient born to a mother with neuromyelitis optica spectrum disorder

Yanyu Chang; Yaqing Shu; Xiaobo Sun; Chengfang Xu; Dan He; Ling Fang; Chen Chen; Xueqiang Hu; Allan Kermode; Wei Qiu

doi:10.1016/j.msard.2017.11.009

Ectrodactyly in a Chinese patient born to a mother with neuromyelitis optica spectrum disorder

Yanyu Chang, Yaqing Shu, Xiaobo Sun, Chengfang Xu, Dan He, Ling Fang, Chen Chen, Xueqiang Hu, Allan Kermode, Wei Qiu

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.

Original language	English
Pages (from-to)	70-72
Number of pages	3
Journal	Multiple Sclerosis and Related Disorders
Volume	19
DOIs	https://doi.org/10.1016/j.msard.2017.11.009
Publication status	Published - 1 Jan 2018

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@article{285c08b3d3e6433f9afeb1de8c0df00a,

title = "Ectrodactyly in a Chinese patient born to a mother with neuromyelitis optica spectrum disorder",

abstract = "NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.",

keywords = "AQP4-IgG, Ectrodactyly, Fetal malformation, Neuromyelitis optica spectrum disorder",

author = "Yanyu Chang and Yaqing Shu and Xiaobo Sun and Chengfang Xu and Dan He and Ling Fang and Chen Chen and Xueqiang Hu and Allan Kermode and Wei Qiu",

year = "2018",

month = jan,

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doi = "10.1016/j.msard.2017.11.009",

language = "English",

volume = "19",

pages = "70--72",

journal = "Multiple Sclerosis and Related Disorders",

issn = "2211-0348",

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TY - JOUR

T1 - Ectrodactyly in a Chinese patient born to a mother with neuromyelitis optica spectrum disorder

AU - Chang, Yanyu

AU - Shu, Yaqing

AU - Sun, Xiaobo

AU - Xu, Chengfang

AU - He, Dan

AU - Fang, Ling

AU - Chen, Chen

AU - Hu, Xueqiang

AU - Kermode, Allan

AU - Qiu, Wei

PY - 2018/1/1

Y1 - 2018/1/1

N2 - NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.

AB - NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.

KW - AQP4-IgG

KW - Ectrodactyly

KW - Fetal malformation

KW - Neuromyelitis optica spectrum disorder

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U2 - 10.1016/j.msard.2017.11.009

DO - 10.1016/j.msard.2017.11.009

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JO - Multiple Sclerosis and Related Disorders

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