TY - JOUR
T1 - Ectrodactyly in a Chinese patient born to a mother with neuromyelitis optica spectrum disorder
AU - Chang, Yanyu
AU - Shu, Yaqing
AU - Sun, Xiaobo
AU - Xu, Chengfang
AU - He, Dan
AU - Fang, Ling
AU - Chen, Chen
AU - Hu, Xueqiang
AU - Kermode, Allan
AU - Qiu, Wei
PY - 2018/1/1
Y1 - 2018/1/1
N2 - NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.
AB - NMOSD develops primarily in women of childbearing age, and several previous studies have shown that the disorder may increase the risk of miscarriage. However, there are no reports, to our knowledge, of fetal malformation, other than neonatal hydrocephalus, related to NMOSD. We report a 30-year-old woman who experienced recurrent neuritis and who was seropositive for AQP4-IgG. She became pregnant, and the fetus was found to have ectrodactyly. Histological analysis of the placenta showed moderate inflammatory infiltration; however, whether fetal malformation in NMOSD is related to inflammation and AQP4-IgG remains to be determined.
KW - AQP4-IgG
KW - Ectrodactyly
KW - Fetal malformation
KW - Neuromyelitis optica spectrum disorder
UR - http://www.scopus.com/inward/record.url?scp=85034047033&partnerID=8YFLogxK
U2 - 10.1016/j.msard.2017.11.009
DO - 10.1016/j.msard.2017.11.009
M3 - Article
C2 - 29149698
AN - SCOPUS:85034047033
VL - 19
SP - 70
EP - 72
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -