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Abstract
Purpose: During the non-attack period, people with migraine may show retinal dysfunction. This study builds on previous work by exploring the possibility of foveal and non-foveal visual field and electroretinographic deficits and determining the overlap in eccentricity of such localized visual deficits in people with migraine. Methods: Visual fields and multifocal electroretinography (mf-ERG) were tested in 27 people with migraine (aged 19-45 years) and 18 non-headache controls (aged 20-46 years). Data were averaged according to 5 concentric rings at < 1.5 degrees (foveal) and 5 degrees, 10 degrees, 15.5 degrees, and 22 degrees eccentricities (non-foveal). Linear mixed effects modelling was used to predict mf-ERG amplitude, mf-ERG peak time, and visual field sensitivity with fixed effects of eye, group, and eccentricity. Results: Foveal mf-ERG responses, and visual field sensitivity across all eccentricities (foveal and non-foveal) were similar between the migraine and control groups (P > 0.05). In contrast, the non-foveal mf-ERG was reduced in amplitude in people with migraine relative to controls (P < 0.001), and this group difference depended on eccentricity (P < 0.001) - most prominently, in the parafoveal region (ring 2, P = 0.001). Conclusions: Retinal electrophysiological deficits were observed in people with migraine in the parafoveal region (between 1.5 degrees and 5 degrees eccentricity), without corresponding visual field deficits. This suggests a spatially localized area of retinal neuronal dysfunction in people with migraine that is insufficient to manifest as a visual field sensitivity loss using standard perimetric methods. Our study highlights the added confound of migraine when conducting standard clinical retinal electrophysiological tests for conditions such as glaucoma, particularly non-foveally.
Original language | English |
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Article number | 44 |
Number of pages | 9 |
Journal | Investigative ophthalmology & visual science |
Volume | 65 |
Issue number | 11 |
DOIs | |
Publication status | Published - Sept 2024 |
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Dive into the research topics of 'Eccentricity Dependency of Retinal Electrophysiological Deficits in People With Episodic Migraine'. Together they form a unique fingerprint.Projects
- 1 Finished
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Cortical Excitation in Migraine: Using Vision to Understand and Track Brain Excitability
McKendrick, A. (Investigator 01), Badcock, D. (Investigator 02) & Vingrys, A. (Investigator 03)
NHMRC National Health and Medical Research Council
1/01/15 → 31/12/18
Project: Research