Early sensory-perceptual changes in huntington's disease

Linda Hayward, Stephen R. Zubrick, Wayne Hall

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Forty-four patients at risk for Huntington's disease and seventeen diagnosed as having the disease were studied longitudinally over a nine-year period to assess the evolution of cognitive impairment. Results showed that there were measurable changes in sensory-perceptual functions well in advance of the emergence of the movement disorder. Discrimination between patients with Huntington's disease and those at risk for the disease based on tests of sensory-perceptual functioning resulted in a correct classification rate of 95.1%. Subjects who had changed from being at risk to having the disease nearly all had discriminant scores from their first test sequence lying in either the disease range or the pre-symptomatic disease range. The present organic model of Huntington's disease is discussed in light of these findings and implications of the mathematical model underlying prediction are discussed.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalAustralian and New Zealand Journal of Psychiatry
Volume19
Issue number4
DOIs
Publication statusPublished - 1 Jan 1985
Externally publishedYes

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