Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy

Kimberley Cw Wang, Kimberley J Botting, Monalisa Padhee, Song Zhang, I Caroline McMillen, Catherine M. Suter, Doug A Brooks, Janna L Morrison

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Epidemiological studies indicate that poor growth before birth is associated with left ventricular hypertrophy and an increased risk of death from heart disease later in life. In fetal life, the insulin-like growth factor (IGF) system has been implicated in physiological growth of the heart, whereas in postnatal life IGFs can be involved in both physiological and pathological cardiac hypertrophy. A reduction in substrate supply in fetal life, resulting in chronic hypoxaemia and intrauterine growth restriction, results in increased cardiac IGF-1R, IGF-2 and IGF-2R gene expression; and there is also evidence for a role of the IGF-2 receptor in the ensuing cardiac hypertrophy. The persistent high level of cardiac IGF-2R gene expression from fetal to postnatal life may be due to epigenetic changes in key cardiac hypertrophy regulatory pathways.

Original languageEnglish
Pages (from-to)958-964
Number of pages7
JournalClinical and Experimental Pharmacology and Physiology
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 2012
Externally publishedYes

Fingerprint Dive into the research topics of 'Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy'. Together they form a unique fingerprint.

  • Cite this