Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Abstract

    1. The Raine study (http://www.rainestudy.org.au, accessed18 June 2012) is a longitudinal Australian birth cohort thathas serially assessed the offspring of 2900 pregnant womenfrom 18 weeks gestation in utero to 17 years of age.2. The Raine study data have shown that low birth weightis a surrogate for poor in utero growth from 18 weeksgestation.3. A U-shaped relationship between birth size and cardiometabolicrisk exists in this Western Australian cohort,implying that both low and high birth weight are associatedwith increased risk.4. High birth weight is a risk factor for cardiometabolicrisk, particularly for females.5. Lifetime adiposity trajectories are better at predictingmetabolic risk of the offspring than birth size or current bodymass index. Therefore, early life programming is an ongoingprocess, starting in utero and undergoing at least some levelof modification in parallel with changes in adiposity duringearly childhood.6. Maternal smoking during pregnancy, maternal obesity,hypertension and diabetes increase the risk for metabolic riskin the offspring. Breast feeding is protective for cardiometabolicrisk in this Australian cohort.
    Original languageEnglish
    Pages (from-to)973-978
    JournalClinical and Experimental Pharmacology and Physiology
    Volume39
    Issue number11
    Early online date29 Oct 2012
    DOIs
    Publication statusPublished - 1 Nov 2012

    Fingerprint Dive into the research topics of 'Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study'. Together they form a unique fingerprint.

  • Cite this