1. The Raine study (http://www.rainestudy.org.au, accessed18 June 2012) is a longitudinal Australian birth cohort thathas serially assessed the offspring of 2900 pregnant womenfrom 18 weeks gestation in utero to 17 years of age.2. The Raine study data have shown that low birth weightis a surrogate for poor in utero growth from 18 weeksgestation.3. A U-shaped relationship between birth size and cardiometabolicrisk exists in this Western Australian cohort,implying that both low and high birth weight are associatedwith increased risk.4. High birth weight is a risk factor for cardiometabolicrisk, particularly for females.5. Lifetime adiposity trajectories are better at predictingmetabolic risk of the offspring than birth size or current bodymass index. Therefore, early life programming is an ongoingprocess, starting in utero and undergoing at least some levelof modification in parallel with changes in adiposity duringearly childhood.6. Maternal smoking during pregnancy, maternal obesity,hypertension and diabetes increase the risk for metabolic riskin the offspring. Breast feeding is protective for cardiometabolicrisk in this Australian cohort.
|Journal||Clinical and Experimental Pharmacology and Physiology|
|Early online date||29 Oct 2012|
|Publication status||Published - 1 Nov 2012|