Early life egg allergen exposure in the primary prevention of egg allergy

Jessica Rene Metcalfe

    Research output: ThesisDoctoral Thesis

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    Abstract

    Background: Food allergy now affects 1 in 10 Australian infants, highhghting the need for effective prevention strategies.
    Methods: I investigated the effect of egg exposure on infant egg-specific immune responses, both with solid foods Introduction and through breast milk.
    Results: Prior to the introduction of solid foods, infants had elevated Th2 cytokine responses to egg that predicted the development of egg allergy. Maternal egg ingestion during in the first 6 weeks of breastfeeding were also shown to beneficially effect egg-specific immune responses in infants.
    Conclusions: These findings highlight an important period of egg specific immune development prior to solid food Introduction.
    Original languageEnglish
    QualificationDoctor of Philosophy
    Awarding Institution
    • The University of Western Australia
    Award date30 Mar 2017
    Publication statusUnpublished - 2017

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