Early atherosclerosis relates to urinary albumin excretion and cardiovascular risk factors in adolescents with type 1 diabetes: Adolescent type 1 Diabetes cardiorenal Intervention Trial (AdDIT)

O. Maftei, A.S. Peña, T. Sullivan, Timothy Jones, K.C. Donaghue, F.J. Cameron, Elizabeth Davis, A.M. Cotterill, M.E. Craig, R.J. Gent, N. Dalton, D. Daneman, D.B. Dunger, J.E. Deanfield, J.J. Couper

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

© 2014 by the American Diabetes Association. OBJECTIVE: The origins of cardiovascular and renal disease in type 1 diabetes begin during childhood. We aimed to evaluate carotid (cIMT) and aortic intima-media thickness (aIMT) and their relationship with cardiovascular risk factors and urinary albumin excretion in adolescents with type 1 diabetes in the Adolescent Type 1 Diabetes cardio-renal Intervention Trial (AdDIT). RESEARCH DESIGN AND METHODS: A total of 406 adolescents with type 1 diabetes, who were 14.1 ± 1.9 years old with type 1 diabetes duration of 6.7 ± 3.7 years, and 57 age-matched control subjects provided clinical and biochemical data and ultrasound measurements of vascular structure (cIMT and aIMT). Vascular endothelial and smooth muscle function was also measured in 123 of 406 with type 1 diabetes and all control subjects. RESULTS: In type 1 diabetic subjects, mean/maximal aIMT (P <0.006;
Original languageEnglish
Pages (from-to)3069-3075
JournalDiabetes Care
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 2014

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