Early and continued manual stimulation is required for long-term recovery after facial nerve injury

Maria Grosheva, Svenja Rink, Ramona Jansen, Habib Bendella, Stoyan P. Pavlov, Levent Sarikcioglu, Doychin N. Angelov, Sarah A. Dunlop

Research output: Contribution to journalArticle

4 Citations (Scopus)
7 Downloads (Pure)

Abstract

Introduction: We previously have shown that manual stimulation (MS) of vibrissal muscles for 2 months after facial nerve injury in rats improves whisking and reduces motor end plate polyinnervation. Here, we seek to determine whether discontinuing or delaying MS after facial-facial anastomosis (FFA) leads to similar results. Methods: Rats were subjected to FFA and received MS for (1) 4 months (early and continued), (2) the first but not the last 2 months (discontinued), or (3) the last 2 months (delayed). Intact animals and those not receiving MS (no MS) were also examined. Results: Early and continued MS restored whisking amplitude to 43°, a value significantly higher compared with the discontinued, delayed, and no MS groups (32°, 24°, and 10°, respectively). Motor end plate polyinnervation occurred in all experimental groups but was significantly higher in the delayed group. Discussion: Early and continued MS results in better recovery than when it is either discontinued or delayed.

Original languageEnglish
Pages (from-to)100-106
Number of pages7
JournalMuscle and Nerve
Volume57
Issue number1
DOIs
Publication statusPublished - 17 Feb 2017

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